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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mahadevaiah, S. K. Rasberry, C. Cooke, H. J. Glenister, P. H. Burgoyne, P. S. Cattanach, B. M. Laval, S. H. Thornton, C. E. |
| Description | Author Affiliation: Laval SH ( Genetics Division, Medical Research Council Radiobiology Unit, Chilton, Dideot, Oxon, United Kingdom.); |
| Abstract | We earlier described three lines of sex-reversed XY female mice deleted for sequences believed close to the testes-determining gene (Sry) on the Y chromosome short arm (Yp). The original sex-reversed females appeared among the offspring of XY males that carried the Yp duplication Sxr on their X chromosome. Earlier cytogenetic observations had suggested that the deletions resulted from asymmetrical meiotic recombination between the Y and the homologous Sxr region, but no direct evidence for this hypothesis was available. We have now analyzed the offspring of XSxr/Y males carrying an evolutionarily divergent Mus musculus domesticus Y chromosome, which permits detection and characterization of such recombination events. This analysis has enabled the derivation of a recombination map of Yp and Sxr, also demonstrating the orientation of Yp with respect to the Y centromere. The mapping data have established that Rbm, the murine homologue of a gene family cloned from the human Y chromosome, lies between Sry and the centromere. Analysis of two additional XY female lines shows that asymmetrical Yp-Sxr recombination leading to XY female sex reversal results in deletion of Rbm sequences. The deletions bring Sry closer to Y centromere, consistent with the hypothesis that position-effect inactivation of Sry is the basis for the sex reversal. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 22 |
| Volume Number | 92 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1995-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Disorders Of Sex Development Gene Deletion Multigene Family Nuclear Proteins Transcription Factors X Chromosome Y Chromosome Animals Biological Evolution Blotting, Southern Chromosome Mapping DNA Primers DNA-Binding Proteins Genetics Genetic Variation Heterozygote Detection Hypoxanthine Phosphoribosyltransferase Mice Mice, Inbred AKR Molecular Sequence Data Polymerase Chain Reaction Recombination, Genetic Restriction Mapping Sex-Determining Region Y Protein Testis Metabolism Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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