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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Saxen, L. Sariola, H. Palgi, J. Saarma, M. Karavanov, A. Sainio, K. |
| Description | Author Affiliation: Karavanov A ( Department of Pathology, University of Helsinki, Finland.); |
| Abstract | We analyzed the developmental regulation and role of the neurotrophins during metanephric kidney morphogenesis. RNase protection assay revealed the presence of nerve growth factor, neurotrophin 3 (NT-3), and brain-derived neurotrophic factor mRNAs and the regulation of their expression during embryonic development of rat metanephros. NT-3 induced differentiation (neurite outgrowth) and survival (inhibition of apoptosis) of the neuronal precursors in cultured nephrogenic mesenchymes and neuronal differentiation in cultured whole kidneys, whereas NT-4/5, brain-derived neurotrophic factor, and nerve growth factor were without effect. The neurotrophins did not trigger tubular differentiation of isolated nephrogenic cells, which underwent apoptosis when cultured with or without the neurotrophins. NT-3 is thus an inducer of differentiation and a survival factor for renal neuronal cells, but none of the neurotrophins is a morphogen in kidney tubule induction. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 92 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1995-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Apoptosis Kidney Embryology Nerve Growth Factors Pharmacology Physiology Neurites Ultrastructure Neurons Cytology Animals Brain-Derived Neurotrophic Factor DNA Primers Chemistry Gene Expression Molecular Sequence Data Genetics Nerve Tissue Proteins Neural Crest Neurotrophin 3 RNA, Messenger Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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