NDLI: Evidence for a novel DNA damage binding protein in human cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1996 Volume: 93 Issue: 26

Year: 1996 Volume: 93 Issue: 25

Year: 1996 Volume: 93 Issue: 24

Year: 1996 Volume: 93 Issue: 23

Year: 1996 Volume: 93 Issue: 22

Year: 1996 Volume: 93 Issue: 21

Year: 1996 Volume: 93 Issue: 20

Year: 1996 Volume: 93 Issue: 19

Year: 1996 Volume: 93 Issue: 18

Year: 1996 Volume: 93 Issue: 17

Year: 1996 Volume: 93 Issue: 16

Year: 1996 Volume: 93 Issue: 15

Year: 1996 Volume: 93 Issue: 14

Natural abundance solid-state carbon NMR studies of photosynthetic reaction centers with photoinduced polarization.

Excitation transfer spectroscopy with two metastable 138Ba+ ions in same trap.

A mechanism for inducing plant development: the genesis of a specific inhibitor.

Chromosome manipulation: a systematic approach toward understanding human chromosome structure and function.

Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry.

Differential display of intestinal mRNAs regulated by dietary zinc.

Ferulate-5-hydroxylase from Arabidopsis thaliana defines a new family of cytochrome P450-dependent monooxygenases.

Molecular mechanics calculations of the riboacetal internucleotide linkage in double and triple helices.

High mobility group I(Y)-like DNA-binding domains on a bacterial transcription factor.

Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis.

Mutational analysis of NM23-H2/NDP kinase identifies the structural domains critical to recognition of a c-myc regulatory element.

The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation.

Mutational analysis and molecular modeling of the nonapeptide hormone binding domains of the [Arg8]vasotocin receptor.

The structure of bovine F1-ATPase complexed with the antibiotic inhibitor aurovertin B.

Evidence for a novel DNA damage binding protein in human cells.

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 93 Issue: 14)

Increased accommodation of nascent RNA in a product site on RNA polymerase II during arrest.

Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

Interactions between tRNA identity nucleotides and their recognition sites in glutaminyl-tRNA synthetase determine the cognate amino acid affinity of the enzyme.

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

Molecular characterization of a FKBP-type immunophilin from higher plants.

Linker histones affect patterns of digestion of supercoiled plasmids by single-strand-specific nucleases.

The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins.

Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif.

Processing of the leader mRNA plays a major role in the induction of thrS expression following threonine starvation in Bacillus subtilis.

Kinetics of photo-induced electron transfer from high-potential iron-sulfur protein to the photosynthetic reaction center of the purple phototroph Rhodoferax fermentans.

Ice as a matrix for IR-matrix-assisted laser desorption/ionization: mass spectra from a protein single crystal.

Structure of the ripple phase in lecithin bilayers.

X-ray structure determination of a metastable state of carbonmonoxy myoglobin after photodissociation.

Three quaternary structures for a single protein.

Direct measurement of oligonucleotide binding stoichiometry of gene V protein by mass spectrometry.

The N-terminal domain of Escherichia coli enzyme I of the phosphoenolpyruvate/glycose phosphotransferase system: molecular cloning and characterization.

The Mos/mitogen-activated protein kinase (MAPK) pathway regulates the size and degradation of the first polar body in maturing mouse oocytes.

The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.

bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations.

Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast.

Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line.

Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.

Bootstrap confidence levels for phylogenetic trees. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 93 Issue: 14)

Does behavior reflect phylogeny in swiftlets (Aves: Apodidae)? A test using cytochrome b mitochondrial DNA sequences.

Naturally occurring variation in copia expression is due to both element (cis) and host (trans) regulatory variation.

Evolutionary changes in the expression pattern of a developmentally essential gene in three Drosophila species.

Selection for genes encoding secreted proteins and receptors.

A change of ploidy can modify epigenetic silencing.

Stabilization of diverged tandem repeats by mismatch repair: evidence for deletion formation via a misaligned replication intermediate.

Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage.

Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication.

CHD1 is concentrated in interbands and puffed regions of Drosophila polytene chromosomes.

ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast.

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.

Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase.

Heterodimer formation and activity in the human enzyme galactose-1-phosphate uridylyltransferase.

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule.

Covalent assembly of a soluble T cell receptor-peptide-major histocompatibility class I complex.

Reduction in the level of Gal(alpha1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase.

Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit.

Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules.

Cellular mechanisms for the formation of a soluble form derivative of T-cell receptor alpha chain by suppressor T cells.

DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines.

U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus.

Correction of diabetic alterations by glucokinase.

Mass vaccination to control chickenpox: the influence of zoster.

Increased liposome extravasation in selected tissues: effect of substance P.

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.

Viral dynamics in vivo: limitations on estimates of intracellular delay and virus decay.

Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.

Cloning and expression of human deoxyguanosine kinase cDNA.

Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.

Cytotoxic analogs of luteinizing hormone-releasing hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent.

Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen.

Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum.

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.

Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal.

Formation of stable cationic lipid/DNA complexes for gene transfer.

Highly stable expression of a foreign gene from rabies virus vectors.

A chromosomal locus required for copper resistance, competitive fitness, and cytochrome c biogenesis in Pseudomonas fluorescens.

A family of lysozyme-like virulence factors in bacterial pathogens of plants and animals.

Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type.

Localization of alpha type II calcium calmodulin-dependent protein kinase at glutamatergic but not gamma-aminobutyric acid (GABAergic) synapses in thalamus and cerebral cortex.

Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex.

Genetic construction and properties of a diphtheria toxin-related substance P fusion protein: in vitro destruction of cells bearing substance P receptors.

Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.

Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma.

Interocular transfer in perceptual learning of a pop-out discrimination task.

Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25.

Alternative splicing of agrin regulates its binding to heparin alpha-dystroglycan, and the cell surface.

Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.

High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries.

Creation of a reversible on/off system for site-specific in vivo control of exogenous gene activity in the renal glomerulus.

Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis.

Hypothalamic integration of body fluid regulation.

Self-recognition and abstraction abilities in the common chimpanzee studied with distorting mirrors.

Structure of murine and human renal type II Na+-phosphate cotransporter genes (Npt2 and NPT2).

Pollen specific expression of maize genes encoding actin depolymerizing factor-like proteins.

Psychophysical evidence for fast region-based segmentation processes in motion and color.

Year: 1996 Volume: 93 Issue: 13

Year: 1996 Volume: 93 Issue: 12

Year: 1996 Volume: 93 Issue: 11

Year: 1996 Volume: 93 Issue: 10

Year: 1996 Volume: 93 Issue: 9

Year: 1996 Volume: 93 Issue: 8

Year: 1996 Volume: 93 Issue: 7

Year: 1996 Volume: 93 Issue: 6

Year: 1996 Volume: 93 Issue: 5

Year: 1996 Volume: 93 Issue: 4

Year: 1996 Volume: 93 Issue: 3

Year: 1996 Volume: 93 Issue: 2

Year: 1996 Volume: 93 Issue: 1

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Evidence for a novel DNA damage binding protein in human cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peng, C. H. Mitchell, D. L. Ghosh, R.
Description	Author Affiliation: Ghosh R ( Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville 78957, USA.);
Abstract	We describe a novel DNA damage binding activity in nuclear extracts from a normal human fibroblast cell strain. This protein was identified using electrophoretic mobility shift assays of immunopurified UV-irradiated oligonucleotide substrates containing a single, site-specific cyclobutane pyrimidine dimer or a pyrimidine (6-4) pyrimidinone photoproduct. Compared with the (6-4) photoproduct, which displayed similar levels of binding in double and single-stranded substrates, the protein showed somewhat lower affinity for the cyclobutane dimer in a single-stranded oligonucleotide and negligible binding in double-stranded DNA. The specificity and magnitude of binding was similar in cells with normal excision repair (GM637) and repair-deficient cells from xeroderma pigmentosum groups A (XP12RO) and E (XP2RO). An apparent molecular mass of 66 kDa consisting of two subunits of approximately 22 and approximately 44 kDa was determined by Southwestern analysis. Cell cycle studies using centrifugal cell elutriation indicated that the binding activity was significantly greater in G1 phase compared with S phase in a human lymphoblast cell line. Gel supershift analysis using an anti-replication protein A antibody showed that the binding protein was not antigenically related to the human single-stranded binding protein. Taken together, these data suggest that this activity represents a novel DNA damage binding protein that, in addition to a putative role in excision repair, may also function in cell cycle or gene regulation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Cycle Cell Nucleus Metabolism DNA Damage DNA-Binding Proteins DNA Radiation Effects Ultraviolet Rays Binding Sites Cell Line Chemistry Isolation & Purification Fibroblasts G1 Phase Lymphocytes Molecular Sequence Data Molecular Weight Oligodeoxyribonucleotides Pyrimidine Dimers S Phase Substrate Specificity Xeroderma Pigmentosum Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in