NDLI: Degradation of CYC1 mRNA in the yeast Saccharomyces cerevisiae does not require translation.

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Degradation of CYC1 mRNA in the yeast Saccharomyces cerevisiae does not require translation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yun, D. F. Sherman, F.
Description	Author Affiliation: Yun DF ( Department of Biochemistry, University of Rochester, School of Medicine and Dentistry, NY 14642, USA.);
Abstract	Several studies have indicated that degradation of certain mRNAs is tightly coupled to their translation, whereas, in contrast, other observations suggested that translation can be inhibited without changing the stability of the mRNA. We have addressed this question with the use of altered CYC1 alleles, which encode iso-1-cytochrome c in the yeast Saccharomyces cerevisiae. The cyc1-1249 mRNA, which lacks all in-frame and out-of-frame AUG triplets, was as stable as the normal mRNA. This finding established that translation is not required for the degradation of CYC1 mRNAs. Furthermore, poly(G)18 tracks were introduced within the CYC1 mRNA translated regions to block exonuclease degradation. The recovery of 3' fragments revealed that the translatable and the AUG-deficient mRNAs are both degraded 5'-->3'. Also, the increased stability of CYC1 mRNAs in xrn1-delta strains lacking Xrn1p, the major 5'-->3' exonuclease, established that the normal and AUG-deficient mRNAs are degraded by the same pathway. In addition, deadenylylation, which activates the action of Xrn1p, occurred at equivalent rates in both normal and AUG-deficient mRNAs. We conclude that translation is not required for the normal degradation of CYC1 mRNAs, and that translatable and untranslated mRNAs are degraded by the same pathway.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytochrome c Group Genetics Cytochromes c Exoribonucleases Protein Biosynthesis RNA, Fungal Metabolism RNA, Messenger Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Codon, Initiator Deoxyribonucleases Fungal Proteins Half-Life Molecular Sequence Data Mutagenesis Poly A Poly G Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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