NDLI: Architectural limits on split genes.

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New infinite families of exact sums of squares formulas, Jacobi elliptic functions, and Ramanujan's tau function.

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Architectural limits on split genes.

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Architectural limits on split genes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sterner, D. A. Carlo, T. Berget, S. M.
Description	Author Affiliation: Sterner DA ( Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA.);
Abstract	Exon/intron architecture varies across the eukaryotic kingdom with large introns and small exons the rule in vertebrates and the opposite in lower eukaryotes. To investigate the relationship between exon and intron size in pre-mRNA processing, internally expanded exons were placed in vertebrate genes with small and large introns. Both exon and intron size influenced splicing phenotype. Intron size dictated if large exons were efficiently recognized. When introns were large, large exons were skipped; when introns were small, the same large exons were included. Thus, large exons were incompatible for splicing if and only if they were flanked by large introns. Both intron and exon size became problematic at approximately 500 nt, although both exon and intron sequence influenced the size at which exons and introns failed to be recognized. These results indicate that present-day gene architecture reflects at least in part limitations on exon recognition. Furthermore, these results strengthen models that invoke pairing of splice sites during recognition of pre-mRNAs, and suggest that vertebrate consensus sequences support pairing across either introns or exons.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Exons Genes Introns Proteins Genetics Adenine Phosphoribosyltransferase Adenosine Deaminase Animals Avian Sarcoma Viruses Cricetinae DNA, Complementary Enhancer Elements, Genetic Hypoxanthine Phosphoribosyltransferase Metallothionein Biosynthesis Mice Ovalbumin Phenotype Polymerase Chain Reaction Promoter Regions, Genetic Vertebrates Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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