NDLI: The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1997 Volume: 94 Issue: 26

Year: 1997 Volume: 94 Issue: 25

Year: 1997 Volume: 94 Issue: 24

Year: 1997 Volume: 94 Issue: 23

Year: 1997 Volume: 94 Issue: 22

Year: 1997 Volume: 94 Issue: 21

Year: 1997 Volume: 94 Issue: 20

Year: 1997 Volume: 94 Issue: 19

Year: 1997 Volume: 94 Issue: 18

Year: 1997 Volume: 94 Issue: 17

Year: 1997 Volume: 94 Issue: 16

Year: 1997 Volume: 94 Issue: 15

Year: 1997 Volume: 94 Issue: 14

Year: 1997 Volume: 94 Issue: 13

Year: 1997 Volume: 94 Issue: 12

Year: 1997 Volume: 94 Issue: 11

Year: 1997 Volume: 94 Issue: 10

Rappaport rules: cleavage furrow induction in animal cells.

Eubacterial signal transduction by ligands of the mammalian peripheral benzodiazepine receptor complex.

Serotonin, sex, and psychiatric illness.

A massage for the journey: keeping leukocytes soft and silent.

Optical trapping and manipulation of neutral particles using lasers.

Ribozyme-mediated high resistance against potato spindle tuber viroid in transgenic potatoes.

Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.

Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position.

Investigation of the mechanisms of DNA binding of the human G/T glycosylase using designed inhibitors.

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase.

Parkinson disease: A new link between monoamine oxidase and mitochondrial electron flow

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.

Mechanism of protein remodeling by ClpA chaperone

A sigma32 mutant with a single amino acid change in the highly conserved region 2.2 exhibits reduced core RNA polymerase affinity.

Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun.

Dual role of the nuclear factor of activated T cells insert region in DNA recognition and cooperative contacts to activator protein 1.

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.

Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms.

In vitro selection and evolution of functional proteins by using ribosome display.

Characterization and tissue-specific expression of the rat basic fibroblast growth factor antisense mRNA and protein.

E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.

Protein binding and signaling properties of RIN1 suggest a unique effector function

Constitutive signaling by the phototaxis receptor sensory rhodopsin II from disruption of its protonated Schiff base-Asp-73 interhelical salt bridge.

Expression, stability, and membrane integration of truncation mutants of bovine rhodopsin.

Three small nucleolar RNAs that are involved in ribosomal RNA precursor processing.

Trigger factor is induced upon cold shock and enhances viability of Escherichia coli at low temperatures.

RNA polymerase sigma factor determines start-site selection but is not required for upstream promoter element activation on heteroduplex (bubble) templates.

Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone.

DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase.

The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer.

Two domains within sigmaN (sigma54) cooperate for DNA binding.

The dTTPase mechanism of T7 DNA helicase resembles the binding change mechanism of the F1-ATPase.

Cross-validated maximum likelihood enhances crystallographic simulated annealing refinement.

The emergence of form by replication.

Reducing the flexibility of retinal restores a wild-type-like photocycle in bacteriorhodopsin mutants defective in protein-retinal coupling.

Signal changes in the spinal cord of the rat after injection of formalin into the hindpaw: characterization using functional magnetic resonance imaging.

A local electrostatic change is the cause of the large-scale protein conformation shift in bacteriorhodopsin.

Cell membrane fluctuations are regulated by medium macroviscosity: evidence for a metabolic driving force.

Karyopherin beta2 mediates nuclear import of a mRNA binding protein.

Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity.

Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor.

Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis.

Microtubule release from the centrosome.

Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules.

Evidence for phosphorylation and oligomeric assembly of presenilin 1

The subcellular localization of E2F-4 is cell-cycle dependent.

A mammalian mitochondrial drug receptor functions as a bacterial 'oxygen' sensor.

Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage.

Channel formation by antiapoptotic protein Bcl-2.

Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva.

Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?

Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells.

Phenotypic alterations in insulin-deficient mutant mice.

Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2.

Population regulation in snowshoe hare and Canadian lynx: asymmetric food web configurations between hare and lynx.

Evolution of paired domains: isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6.

The origin and evolution of animal appendages.

Population dynamics, demographic stochasticity, and the evolution of cooperation.

A natural classification of the basic helix-loop-helix class of transcription factors.

Molecular origin of the mosaic sequence arrangements of higher primate alpha-globin duplication units.

Four primordial modes of tRNA-synthetase recognition, determined by the (G,C) operational code.

An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs.

P element insertion-dependent gene activation in the Drosophila eye.

The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae.

Functional domains are specified to single-cell resolution in a Drosophila epithelium.

Clustering of meiotic double-strand breaks on yeast chromosome III.

An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.

Multiple-complete-digest restriction fragment mapping: generating sequence-ready maps for large-scale DNA sequencing.

Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.

Characteristic enrichment of DNA repeats in different genomes.

Identification of nitric oxide synthase as a protective locus against tuberculosis

The alpha1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?

The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers.

A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells.

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor.

High-affinity binding of bioactive glycosylation-inhibiting factor to antigen-primed T cells and natural killer cells.

Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells.

Prevention of autoimmune disease due to lymphocyte modulation by the B-subunit of Escherichia coli heat-labile enterotoxin.

Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease.

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.

Differences between males and females in rates of serotonin synthesis in human brain.

Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in $Cpe^{fat}$ mice associated with a carboxypeptidase E mutation

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.

Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression.

Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.

The leukocyte response to fluid stress

Comparison of parametric and nonparametric methods to map oligogenes by linkage.

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.

Functional antioxidant responsive elements.

Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis.

Thioredoxin-linked mitigation of allergic responses to wheat.

Experimental surgery to create subgenomes of Bacillus subtilis 168.

Chaperonin filaments: The archaeal cytoskeleton?

Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells.

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation.

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits.

Interaction of the synprint site of N-type $Ca^{2+}$ channels with the C2B domain of synaptotagmin I

The structure and precision of retinal spike trains.

Novel form of crosstalk between G protein and tyrosine kinase pathways

Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation.

Voltage-controlled gating in a large conductance $Ca^{2+}-sensitive$ $K^{+}channel (hslo)$

Peptidyl prolyl cis-trans isomerase activity of cyclophilin A in functional homo-oligomeric receptor expression.

Neural mechanisms underlying binocular fusion and stereopsis: position vs. phase.

Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct.

Scanning mutagenesis of the putative transmembrane segments of $K_{ir}2.1,$ an inward rectifier potassium channel

A novel multifunctional O-methyltransferase implicated in a dual methylation pathway associated with lignin biosynthesis in loblolly pine.

Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis.

Rhizobium gone native: unexpected plasmid stability of indigenous Rhizobium leguminosarum.

Cultural universals: measuring the semantic structure of emotion terms in English and Japanese.

Year: 1997 Volume: 94 Issue: 9

Year: 1997 Volume: 94 Issue: 8

Year: 1997 Volume: 94 Issue: 7

Year: 1997 Volume: 94 Issue: 6

Year: 1997 Volume: 94 Issue: 5

Year: 1997 Volume: 94 Issue: 4

Year: 1997 Volume: 94 Issue: 3

Year: 1997 Volume: 94 Issue: 2

Year: 1997 Volume: 94 Issue: 1

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Linder, P. Iost, I. De La Cruz, J. Kressler, D.
Description	Author Affiliation: de la Cruz J ( Département de Biochimie Médicale, CMU, 1, rue Michel Servet, 1211 Genève 4, Switzerland.);
Abstract	The translation initiation factor eIF4E mediates the binding of the small ribosomal subunit to the cap structure at the 5' end of the mRNA. In Saccharomyces cerevisiae, the cap-binding protein eIF4E is mainly associated with eIF4G, forming the cap-binding complex eIF4F. Other proteins are detected upon purification of the complex on cap-affinity columns. Among them is p20, a protein of unknown function encoded by the CAF20 gene. Here, we show a negative regulatory role for the p20 protein in translation initiation. Deletion of CAF20 partially suppresses mutations in translation initiation factors. Overexpression of the p20 protein results in a synthetic enhancement of translation mutation phenotypes. Similar effects are observed for mutations in the DED1 gene, which we have isolated as a multicopy suppressor of a temperature-sensitive eIF4E mutation. The DED1 gene encodes a putative RNA helicase of the DEAD-box family. The analyses of its suppressor activity, of polysome profiles of ded1 mutant strains, and of synthetic lethal interactions with different translation mutants indicate that the Ded1 protein has a role in translation initiation in S. cerevisiae.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation, Fungal Genes, Suppressor Peptide Initiation Factors Metabolism Protein Biosynthesis RNA Nucleotidyltransferases RNA-Binding Proteins Saccharomyces Cerevisiae Cloning, Molecular DNA Primers Escherichia Coli Eukaryotic Initiation Factor-4E Genes, Fungal Genes, Lethal Mutagenesis Polymerase Chain Reaction Polyribosomes RNA Cap-Binding Proteins RNA Helicases Genetics Growth & Development Temperature Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in