NDLI: The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1997 Volume: 94 Issue: 26

Year: 1997 Volume: 94 Issue: 25

Year: 1997 Volume: 94 Issue: 24

Year: 1997 Volume: 94 Issue: 23

Year: 1997 Volume: 94 Issue: 22

Year: 1997 Volume: 94 Issue: 21

Year: 1997 Volume: 94 Issue: 20

Year: 1997 Volume: 94 Issue: 19

Year: 1997 Volume: 94 Issue: 18

Year: 1997 Volume: 94 Issue: 17

Year: 1997 Volume: 94 Issue: 16

Year: 1997 Volume: 94 Issue: 15

Year: 1997 Volume: 94 Issue: 14

Hepatitis B virus, the vaccine, and the control of primary cancer of the liver.

Natural and unnatural answers to evolutionary questions.

Contacting the protein folding funnel with NMR.

BRCA1 is a cell cycle-regulated nuclear phosphoprotein.

The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase

RAP74 induces promoter contacts by RNA polymerase II upstream and downstream of a DNA bend centered on the TATA box.

Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation.

X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase.

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

ETS target genes: identification of egr1 as a target by RNA differential display and whole genome PCR techniques.

The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.

Detection of residue contacts in a protein folding intermediate.

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner.

Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.

Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1.

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.

Posttranscriptional modification of retroviral primers is required for late stages of DNA replication.

The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.

Slow dimer dissociation of the TATA binding protein dictates the kinetics of DNA binding.

The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc.

Gene cloning, sequence analysis, and expression of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase.

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression.

Distinct roles for E2F proteins in cell growth control and apoptosis.

Multiprotein bridging factor 1 (MBF1) is an evolutionarily conserved transcriptional coactivator that connects a regulatory factor and TATA element-binding protein.

Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro.

A model of excitation and adaptation in bacterial chemotaxis.

HLA class I and II antigens are partially co-clustered in the plasma membrane of human lymphoblastoid cells.

Movements of truncated kinesin fragments with a short or an artificial flexible neck.

Prion protein NMR structure and species barrier for prion diseases.

Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein.

Fas-induced apoptosis of T cells occurs independently of ceramide generation.

Structural protein 4.1 is located in mammalian centrosomes.

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.

The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria.

In vivo zippering of inner and outer mitochondrial membranes by a stable translocation intermediate.

Ethanolamine modulates the rate of rat hepatocyte proliferation in vitro and in vivo.

Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.

Mso1p: A yeast protein that functions in secretion and interacts physically and genetically with Sec1p

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.

Distinct mechanisms of splicing regulation in vivo by the Drosophila protein Sex-lethal.

Suspensor-derived polyembryony caused by altered expression of valyl-tRNA synthetase in the twn2 mutant of Arabidopsis.

Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver.

Evolution of plastid gene rps2 in a lineage of hemiparasitic and holoparasitic plants: many losses of photosynthesis and complex patterns of rate variation.

Evolution of foraging behavior in Drosophila by density-dependent selection.

Substantial narrowing of the Niemann-Pick C candidate interval by yeast artificial chromosome complementation.

Direct isolation of human BRCA2 gene by transformation-associated recombination in yeast.

Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.

Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genes.

Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes

Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5.

Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis.

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats.

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

Specific cleavage of chromosomal and plasmid DNA strands in gram-positive and gram-negative bacteria can be detected with nucleotide resolution.

Position- and orientation-independent activity of the Schizosaccharomyces pombe meiotic recombination hot spot M26.

Evolution of the Friedreich's ataxia trinucleotide repeat expansion: founder effect and premutations.

Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract.

A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly.

Gene replacement by homologous recombination in the multicellular green alga Volvox carteri.

Three novel families of miniature inverted-repeat transposable elements are associated with genes of the yellow fever mosquito, Aedes aegypti.

hCTR1: A human gene for copper uptake identified by complementation in yeast

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2.

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP.

Recombinant parvovirus-like particles as an antigen carrier: a novel nonreplicative exogenous antigen to elicit protective antiviral cytotoxic T cells.

Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells.

Proteasome regulation of activation-induced T cell death.

The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein.

A new class of obesity genes encodes leukocyte adhesion receptors.

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease.

Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone.

Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.

Gestational exposure to ethanol suppresses msx2 expression in developing mouse embryos.

Reduced fertility in mice deficient for the POU protein sperm-1.

Up-regulation of specific tyrosinase mRNAs in mouse melanomas with the c2j gene substituted for the wild-type tyrosinase allele: utilization in design of syngeneic immunotherapy models.

Chemical camouflage of antigenic determinants: stealth erythrocytes.

Transcription and activity of antioxidant enzymes after ionizing irradiation in radiation-resistant and radiation-sensitive mice

Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells.

Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis.

GPIIIa-(49-66) is a major pathophysiologically relevant antigenic determinant for anti-platelet GPIIIa of HIV-1-related immunologic thrombocytopenia.

Induction of host signal transduction pathways by Helicobacter pylori.

CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B.

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant.

Aggregation and disaggregation of senile plaques in Alzheimer disease.

Functional impact of cerebral connections.

Visual stimuli induce waves of electrical activity in turtle cortex.

Positron-emission tomography imaging of long-term shape recognition challenges.

Transmembrane topology of a CLC chloride channel.

A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter.

Head direction cells and episodic spatial information in rats without a hippocampus.

Streaming potential measurements in αβγ-rat epithelial $Na^{+}channel$ in planar lipid bilayers

Slow cycling of unphosphorylated myosin is inhibited by calponin, thus keeping smooth muscle relaxed.

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

Striking sequence similarity in inter- and intra-specific comparisons of class I SLG alleles from Brassica oleracea and Brassica campestris: implications for the evolution and recognition mechanism.

A reversibly glycosylated polypeptide (RGP1) possibly involved in plant cell wall synthesis: purification, gene cloning, and trans-Golgi localization.

A maize zinc-finger protein binds the prolamin box in zein gene promoters and interacts with the basic leucine zipper transcriptional activator Opaque2.

Year: 1997 Volume: 94 Issue: 13

Year: 1997 Volume: 94 Issue: 12

Year: 1997 Volume: 94 Issue: 11

Year: 1997 Volume: 94 Issue: 10

Year: 1997 Volume: 94 Issue: 9

Year: 1997 Volume: 94 Issue: 8

Year: 1997 Volume: 94 Issue: 7

Year: 1997 Volume: 94 Issue: 6

Year: 1997 Volume: 94 Issue: 5

Year: 1997 Volume: 94 Issue: 4

Year: 1997 Volume: 94 Issue: 3

Year: 1997 Volume: 94 Issue: 2

Year: 1997 Volume: 94 Issue: 1

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chung, D. W. Côté, H. C. Davie, E. W. Pratt, K. P. Stenkamp, R. E.
Description	Author Affiliation: Pratt KP ( Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. kpratt@u.washington.edu);
Abstract	After vascular injury, a cascade of serine protease activations leads to the conversion of the soluble fibrinogen molecule into fibrin. The fibrin monomers then polymerize spontaneously and noncovalently to form a fibrin gel. The primary interaction of this polymerization reaction is between the newly exposed N-terminal Gly-Pro-Arg sequence of the alpha chain of one fibrin molecule and the C-terminal region of a gamma chain of an adjacent fibrin(ogen) molecule. In this report, the polymerization pocket has been identified by determining the crystal structure of a 30-kDa C-terminal fragment of the fibrin(ogen) gamma chain complexed with the peptide Gly-Pro-Arg-Pro. This peptide mimics the N terminus of the alpha chain of fibrin. The conformational change in the protein upon binding the peptide is subtle, with electrostatic interactions primarily mediating the association. This is consistent with biophysical experiments carried out over the last 50 years on this fundamental polymerization reaction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fibrin Chemistry Oligopeptides Dimerization Metabolism Models, Molecular Molecular Sequence Data Protein Conformation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in