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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Duncan, R. Li, H. P. Comai, L. Zhang, X. Lai, M. M. |
| Description | Author Affiliation: Li HP ( Department of Molecular Microbiology and Immunology, University of Southern California Schools of Medicine, Los Angeles, CA 90033, USA.); |
| Abstract | A cellular protein, previously described as p35/38, binds to the complementary (-)-strand of the leader RNA and intergenic (IG) sequence of mouse hepatitis virus (MHV) RNA. The extent of the binding of this protein to IG sites correlates with the efficiency of the subgenomic mRNA transcription from that IG site, suggesting that it is a requisite transcription factor. We have purified this protein and determined by partial peptide sequencing that it is heterogeneous nuclear ribonucleoprotein (hnRNP) A1, an abundant, primarily nuclear protein. hnRNP A1 shuttles between the nucleus and cytoplasm and plays a role in the regulation of alternative RNA splicing. The MHV(-)-strand leader and IG sequences conform to the consensus binding motifs of hnRNP A1. Recombinant hnRNP A1 bound to these two RNA regions in vitro in a sequence-specific manner. During MHV infection, hnRNP A1 relocalizes from the nucleus to the cytoplasm, where viral replication occurs. These data suggest that hnRNP A1 is a cellular factor that regulates the RNA-dependent RNA transcription of the virus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 18 |
| Volume Number | 94 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1997-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Coronavirus Infections Genetics Gene Expression Regulation, Viral Heterogeneous-Nuclear Ribonucleoprotein Group A-B Murine Hepatitis Virus RNA, Viral Ribonucleoproteins Animals Virology Heterogeneous-Nuclear Ribonucleoproteins Mice RNA, Heterogeneous Nuclear Metabolism RNA-Binding Proteins Recombinant Proteins Transcription, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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