NDLI: The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII130 and mediates long-range activation of the alpha- and beta-globin gene loci in an erythroid cell line.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1997 Volume: 94 Issue: 26

Year: 1997 Volume: 94 Issue: 25

Year: 1997 Volume: 94 Issue: 24

Year: 1997 Volume: 94 Issue: 23

Year: 1997 Volume: 94 Issue: 22

Year: 1997 Volume: 94 Issue: 21

Year: 1997 Volume: 94 Issue: 20

Year: 1997 Volume: 94 Issue: 19

When protein engineering confronts the tRNA world.

Minimized protein structures: a little goes a long way.

A new prion controls fungal cell fusion incompatibility.

Rational protein design: combining theory and experiment.

A vaccine for HIV type 1: the antibody perspective.

ActA is a dimer.

Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase.

A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes.

The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII130 and mediates long-range activation of the alpha- and beta-globin gene loci in an erythroid cell line.

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control.

Phage display of a catalytic antibody to optimize affinity for transition-state analog binding.

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation.

Characterization of human telomerase complex.

Structural mimicry of a native protein by a minimized binding domain.

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.

Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo.

The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs.

RNA folding kinetics regulates translation of phage MS2 maturation gene.

The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.

Selection and nuclear immobilization of exportable RNAs.

Glutamic acid 286 in subunit I of cytochrome bo3 is involved in proton translocation.

Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex.

Cloning and characterization of the mouse vitamin D receptor promoter.

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair.

Specific atomic groups and RNA helix geometry in acceptor stem recognition by a tRNA synthetase.

In vitro properties of the first ORF protein from mouse LINE-1 support its role in ribonucleoprotein particle formation during retrotransposition.

Exploring the folding free energy surface of a three-helix bundle protein.

The lipid bilayer determines helical tilt angle and function in lactose permease of Escherichia coli.

Probing the role of packing specificity in protein design.

Lipochitooligosaccharide-induced tobacco cells release a peptide as mediator of the glycolipid signal. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 94 Issue: 19)

Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).

The alpha chain of laminin-1 is independently secreted and drives secretion of its beta- and gamma-chain partners.

Gravity and the orientation of cell division.

Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas.

Vitamin A in serum is a survival factor for fibroblasts.

Mutations of Arabidopsis thaliana that transform leaves into cotyledons.

Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome.

Elasmobranchs express separate cholecystokinin and gastrin genes.

Compositional differences within and between eukaryotic genomes.

Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa.

Altered 3'-terminal RNA structure in phage Qbeta adapted to host factor-less Escherichia coli.

Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.

Calx, a Na-Ca exchanger gene of Drosophila melanogaster.

Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase.

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern.

DNA typing in thirty seconds with a microfabricated device.

Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells.

Expression of HLA class I-specific inhibitory natural killer cell receptors in HIV-specific cytolytic T lymphocytes: impairment of specific cytolytic functions.

Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses.

Hemato-lymphoid in vivo reconstitution potential of subpopulations derived from in vitro differentiated embryonic stem cells

Antibodies to ribosomal P proteins of Trypanosoma cruzi in Chagas disease possess functional autoreactivity with heart tissue and differ from anti-P autoantibodies in lupus

A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5.

The identification of CD4+ T cell epitopes with dedicated synthetic peptide libraries.

Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector.

A variant of DNA polymerase beta acts as a dominant negative mutant.

Beta-catenin mutations in cell lines established from human colorectal cancers.

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.

Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1alpha and its dual block by ovarian steroids.

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain.

Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.

The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins).

Search for the pathogenesis of the differing phenotype in two compound heterozygote Hungarian brothers with the same genotypic triosephosphate isomerase deficiency

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.

Direct isolation of human transcribed sequences from yeast artificial chromosomes through the application of RNA fingerprinting.

The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site.

Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death.

The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain.

FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects.

Context-sensitive synaptic plasticity and temporal-to-spatial transformations in hippocampal slices.

Genetic influence on neurogenesis in the dentate gyrus of adult mice.

Impaired long-term potentiation induction in dentate gyrus of calretinin-deficient mice

Representation of sound localization cues in the auditory thalamus of the barn owl.

Excitatory-inhibitory network in the visual cortex: psychophysical evidence.

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures.

A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans.

Control of time-dependent biological processes by temporally patterned input.

Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor.

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.

RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying $K^{+} channels$

A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway.

Dinor-oxo-phytodienoic acid: a new hexadecanoid signal in the jasmonate family.

CP12 provides a new mode of light regulation of Calvin cycle activity in higher plants

Year: 1997 Volume: 94 Issue: 18

Year: 1997 Volume: 94 Issue: 17

Year: 1997 Volume: 94 Issue: 16

Year: 1997 Volume: 94 Issue: 15

Year: 1997 Volume: 94 Issue: 14

Year: 1997 Volume: 94 Issue: 13

Year: 1997 Volume: 94 Issue: 12

Year: 1997 Volume: 94 Issue: 11

Year: 1997 Volume: 94 Issue: 10

Year: 1997 Volume: 94 Issue: 9

Year: 1997 Volume: 94 Issue: 8

Year: 1997 Volume: 94 Issue: 7

Year: 1997 Volume: 94 Issue: 6

Year: 1997 Volume: 94 Issue: 5

Year: 1997 Volume: 94 Issue: 4

Year: 1997 Volume: 94 Issue: 3

Year: 1997 Volume: 94 Issue: 2

Year: 1997 Volume: 94 Issue: 1

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII130 and mediates long-range activation of the alpha- and beta-globin gene loci in an erythroid cell line.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ramamurthy, L. Cunningham, J. M. Tanese, N. Saluja, D. Jane, S. M. Amrolia, P. J.
Description	Author Affiliation: Amrolia PJ ( Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN 38101, USA.);
Abstract	We have used the interaction between the erythroid-specific enhancer in hypersensitivity site 2 of the human beta-globin locus control region and the globin gene promoters as a paradigm to examine the mechanisms governing promoter/enhancer interactions in this locus. We have demonstrated that enhancer-dependent activation of the globin promoters is dependent on the presence of both a TATA box in the proximal promoter and the binding site for the erythroid-specific heteromeric transcription factor NF-E2 in the enhancer. Mutational analysis of the transcriptionally active component of NF-E2, p45NF-E2, localizes the critical region for this function to a proline-rich transcriptional activation domain in the NH2-terminal 80 amino acids of the protein. In contrast to the wild-type protein, expression of p45 NF-E2 lacking this activation domain in an NF-E2 null cell line fails to support enhancer-dependent transcription in transient assays. More significantly, the mutated protein also fails to reactivate expression of the endogenous beta- or alpha-globin loci in this cell line. Protein-protein interaction studies reveal that this domain of p45 NF-E2 binds specifically to a component of the transcription initiation complex, TATA binding protein associated factor TAFII130. These findings suggest one potential mechanism for direct recruitment of distal regulatory regions of the globin loci to the individual promoters.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Metabolism Globins Genetics Leukemia, Erythroblastic, Acute Pathology TATA-Binding Protein Associated Factors Transcription Factor TFIID Transcription Factors Binding Sites Chemistry Enhancer Elements, Genetic Erythroid-Specific DNA-Binding Factors Gene Expression NF-E2 Transcription Factor NF-E2 Transcription Factor, P45 Subunit Protein Binding TATA Box Transcriptional Activation Tumor Cells, Cultured Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in