NDLI: Trajectory of DNA in the RNA polymerase II transcription preinitiation complex.

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Trajectory of DNA in the RNA polymerase II transcription preinitiation complex.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lagrange, T. Wang, Y. H. Kim, T. K. Griffith, J. D. Reinberg, D. Ebright, R. H.
Description	Author Affiliation: Kim TK ( Howard Hughes Medical Institute and Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.);
Abstract	By using site-specific protein-DNA photocrosslinking, we define the positions of TATA-binding protein, transcription factor IIB, transcription factor IIF, and subunits of RNA polymerase II (RNAPII) relative to promoter DNA within the human transcription preinitiation complex. The results indicate that the interface between the largest and second-largest subunits of RNAPII forms an extended, approximately 240 A channel that interacts with promoter DNA both upstream and downstream of the transcription start. By using electron microscopy, we show that RNAPII compacts promoter DNA by the equivalent of approximately 50 bp. Together with the published structure of RNAPII, the results indicate that RNAPII wraps DNA around its surface and suggest a specific model for the trajectory of the wrapped DNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Directed RNA Polymerases Chemistry DNA Transcription, Genetic Animals Cross-Linking Reagents Genetics Ultrastructure Microscopy, Electron Molecular Sequence Data Nucleic Acid Conformation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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