NDLI: Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.

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Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.

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Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Beavo, J. A. Soderling, S. H. Bayuga, S. J.
Description	Author Affiliation: Soderling SH ( Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.);
Abstract	We report here the cloning, expression, and characterization of a dual-substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE) from mouse. This PDE contains the consensus sequence for a PDE catalytic domain, but shares <50% sequence identity with the catalytic domains of all other known PDEs and, therefore, represents a new PDE gene family, designated PDE10A. The cDNA for PDE10A is 3, 370 nt in length. It includes a full ORF, contains three in-frame stop codons upstream of the first methionine, and is predicted to encode a 779-aa enzyme. At the N terminus PDE10A has two GAF domains homologous to many signaling molecules, including PDE2, PDE5, and PDE6, which likely constitute a low-affinity binding site for cGMP. PDE10A hydrolyzes cAMP with a Km of 0.05 microM and cGMP with a Km of 3 microM. Although PDE10A has a lower Km for cAMP, the Vmax ratio (cGMP/cAMP) is 4.7. RNA distribution studies indicate that PDE10A is expressed at highest levels in testis and brain.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	3',5'-Cyclic-AMP Phosphodiesterases Genetics 3',5'-Cyclic-GMP Phosphodiesterases Phosphoric Diester Hydrolases Metabolism Amino Acid Sequence Animals Cloning, Molecular Cyclic AMP Cyclic GMP Mice Molecular Sequence Data Sequence Alignment Substrate Specificity Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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