NDLI: The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury.

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The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury.

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The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Thompson, C. S. Mackenzie, A. E. Korneluk, R. G. Holcik, M. Yaraghi, Z. Lefebvre, C. A.
Description	Author Affiliation: Holcik M ( Solange Gauthier Karsh Molecular Genetics Laboratory, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON Canada K1H 8L1.);
Abstract	The neuronal apoptosis inhibitory protein (NAIP) is a member of a novel family of inhibitor of apoptosis (IAP) proteins. The IAP genes are highly conserved from baculovirus to metazoans and suppress apoptosis induced by a variety of triggers both in vitro and in vivo. Here we describe the generation and characterization of mice with the targeted deletion of NAIP1. We demonstrate that the NAIP1-deleted mice develop normally. However, the survival of pyramidal neurons in the hippocampus after kainic acid-induced limbic seizures is greatly reduced in the NAIP1 knock-out animals. Thus, although NAIP1 is not necessary for normal development of murine central nervous system, the endogenous NAIP1 is required for neuronal survival in pathological conditions.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Drug Effects Excitatory Amino Acid Agonists Pharmacology Hippocampus Cytology Kainic Acid Nerve Tissue Proteins Physiology Neurons Animals Mice Mice, Knockout Genetics Neuronal Apoptosis-Inhibitory Protein Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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