NDLI: KCNQ4, a $K^{+}$ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway

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KCNQ4, a $K^{+}$ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway

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KCNQ4, a $K^{+}$ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hardelin, J. P. El-amraoui, A. Petit, C. Jentsch, T. J. Kharkovets, T. Schweizer, M. Safieddine, S.
Description	Author Affiliation: Kharkovets T ( Zentrum für Molekulare Neurobiologie Hamburg, Universität Hamburg, Martinistrasse 85, D-20246 Hamburg, Germany.);
Abstract	Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been found exclusively in the outer hair cells. By using specific antibodies, we now show that KCNQ4 is situated at the basal membrane of these sensory cells. In the vestibular organs, KCNQ4 is restricted to the type I hair cells and the afferent calyx-like nerve endings ensheathing these sensory cells. Several lines of evidence suggest that KCNQ4 underlies the I(K,n) and g(K,L) currents that have been described in the outer and type I hair cells, respectively, and that are already open at resting potentials. KCNQ4 is also expressed in neurons of many, but not all, nuclei of the central auditory pathway, and is absent from most other brain regions. It is present, e.g., in the cochlear nuclei, the nuclei of the lateral lemniscus, and the inferior colliculus. This is the first ion channel shown to be specifically expressed in a sensory pathway. Moreover, the expression pattern of KCNQ4 in the mouse auditory system raises the possibility of a central component in the DFNA2 hearing loss.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Auditory Pathways Metabolism Ear, Inner Genes, Dominant Hearing Loss, Sensorineural Genetics Potassium Channels, Voltage-Gated Potassium Channels Amino Acid Sequence Animals Brain COS Cells Ultrastructure Immunohistochemistry In Situ Hybridization KCNQ Potassium Channels Mice Mice, Inbred C3H Microscopy, Electron Molecular Sequence Data Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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