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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lambert, L. A. Polis, M. A. Dewar, R. L. Dimitrov, D. S. Baseler, M. W. Bosche, M. C. Kovacs, J. A. Natarajan, V. Alvord, W. G. Adelsberger, J. W. Stevens, R. A. Lane, H. C. Metcalf, J. A. Davey, R. T. Lempicki, R. A. |
| Description | Author Affiliation: Lempicki RA ( Science Applications International Corporation-Frederick, Clinical Services Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.); |
| Abstract | To evaluate the effects of HIV infection on T cell turnover, we examined levels of DNA synthesis in lymph node and peripheral blood mononuclear cell subsets by using ex vivo labeling with BrdUrd. Compared with healthy controls (n = 67), HIV-infected patients (n = 57) had significant increases in the number and fraction of dividing CD4(+) and CD8(+) T cells. Higher percentages of dividing CD4(+) and CD8(+) T cells were noted in patients with the higher viral burdens. No direct correlation was noted between rates of T cell turnover and CD4(+) T cell counts. Marked reductions in CD4(+) and CD8(+) T cell proliferation were seen in 11/11 patients 1-12 weeks after initiation of highly active antiretroviral therapy (HAART). These reductions persisted for the length of the study (16-72 weeks). Decreases in naive T cell proliferation correlated with increases in the levels of T cell receptor rearrangement excision circles. Division of CD4(+) and CD8(+) T cells increased dramatically in association with rapid increases in HIV-1 viral loads in 9/9 patients 5 weeks after termination of HAART and declined to pre-HAART-termination levels 8 weeks after reinitiation of therapy. These data are consistent with the hypothesis that HIV-1 infection induces a viral burden-related, global activation of the immune system, leading to increases in lymphocyte proliferation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 25 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antiretroviral Therapy, Highly Active CD4-Positive T-Lymphocytes Immunology CD8-Positive T-Lymphocytes HIV Infections Antigens, CD45 Cytology Cell Division Flow Cytometry HIV-1 Isolation & Purification Receptors, Antigen, T-Cell Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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