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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Knowles, D. P. Brayton, K. A. Mcguire, T. C. Palmer, G. H. |
| Description | Author Affiliation: Brayton KA ( Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA. kbrayton@vetmed.wsu.edu); |
| Abstract | Ehrlichiae are responsible for important tick-transmitted diseases, including anaplasmosis, the most prevalent tick-borne infection of livestock worldwide, and the emerging human diseases monocytic and granulocytic ehrlichiosis. Antigenic variation of major surface proteins is a key feature of these pathogens that allows persistence in the mammalian host, a requisite for subsequent tick transmission. In Anaplasma marginale pseudogenes for two antigenically variable gene families, msp2 and msp3, appear in concert. These pseudogenes can be recombined into the functional expression site to generate new antigenic variants. Coordinated control of the recombination of these genes would allow these two gene families to act synergistically to evade the host immune response. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Bacterial Genetics Bacterial Outer Membrane Proteins Bacterial Proteins Ehrlichia Amino Acid Sequence Animals Ehrlichiosis Microbiology Epitopes Genetic Variation Genome, Bacterial Molecular Sequence Data Pseudogenes Sequence Homology, Amino Acid Tick-Borne Diseases Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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