NDLI: Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys.

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Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys.

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Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weindruch, R. Kayo, T. Prolla, T. A. Allison, D. B.
Description	Author Affiliation: Kayo T ( Wisconsin Regional Primate Research Center, Madison, WI 53715, USA.);
Abstract	In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins. We have previously used high-density oligonucleotide arrays to show that CR can prevent or delay most of the major age-related transcriptional alterations in the gastrocnemius muscle of C57BL/6 mice. Here we report the effects of aging and adult-onset CR on the gene expression profile of 7,070 genes in the vastus lateralis muscle from rhesus monkeys. Gene expression analysis of aged rhesus monkeys (mean age of 26 years) was compared with that of young animals (mean age of 8 years). Aging resulted in a selective up-regulation of transcripts involved in inflammation and oxidative stress, and a down-regulation of genes involved in mitochondrial electron transport and oxidative phosphorylation. Middle-aged monkeys (mean age of 20 years) subjected to CR since early adulthood (mean age of 11 years) were studied to determine the gene expression profile induced by CR. CR resulted in an up-regulation of cytoskeletal protein-encoding genes, and also a decrease in the expression of genes involved in mitochondrial bioenergetics. Surprisingly, we did not observe any evidence for an inhibitory effect of adult-onset CR on age-related changes in gene expression. These results indicate that the induction of an oxidative stress-induced transcriptional response may be a common feature of aging in skeletal muscle of rodents and primates, but the extent to which CR modifies these responses may be species-specific.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Genetics Food Deprivation Physiology Gene Expression Profiling Macaca Mulatta Muscle, Skeletal Metabolism Transcription, Genetic Animals Down-Regulation Electron Transport Energy Intake Oligonucleotide Array Sequence Analysis Oxidative Phosphorylation Oxidative Stress RNA, Messenger Up-Regulation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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