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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kirschning, C. J. Häcker, H. Redecke, V. Bauer, S. Wagner, H. Hausmann, S. Lipford, G. B. Akira, S. |
| Description | Author Affiliation: Bauer S ( Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany. stefan.bauer@lrz.tum.de); |
| Abstract | The Toll-like receptor (TLR) family consists of phylogenetically conserved transmembrane proteins, which function as mediators of innate immunity for recognition of pathogen-derived ligands and subsequent cell activation via the Toll/IL-1R signal pathway. Here, we show that human TLR9 (hTLR9) expression in human immune cells correlates with responsiveness to bacterial deoxycytidylate-phosphate-deoxyguanylate (CpG)-DNA. Notably 'gain of function' to immunostimulatory CpG-DNA is achieved by expressing TLR9 in human nonresponder cells. Transfection of either human or murine TLR9 conferred responsiveness in a CD14- and MD2-independent manner, yet required species-specific CpG-DNA motifs for initiation of the Toll/IL-1R signal pathway via MyD88. The optimal CpG motif for hTLR9 was GTCGTT, whereas the optimal murine sequence was GACGTT. Overall, these data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating CpG-DNA. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | CpG Islands DNA, Bacterial Immunology DNA-Binding Proteins Receptors, Cell Surface Animals Cell Line DNA Primers DNA, Complementary Genetics Genetic Complementation Test Mice Molecular Sequence Data Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Species Specificity Toll-Like Receptor 9 Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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