NDLI: HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2001 Volume: 98 Issue: 26

Year: 2001 Volume: 98 Issue: 25

Year: 2001 Volume: 98 Issue: 24

Year: 2001 Volume: 98 Issue: 23

Year: 2001 Volume: 98 Issue: 22

Year: 2001 Volume: 98 Issue: 21

Year: 2001 Volume: 98 Issue: 20

Year: 2001 Volume: 98 Issue: 19

Year: 2001 Volume: 98 Issue: 18

Year: 2001 Volume: 98 Issue: 17

A role for muscarinic excitation: control of specific singing behavior by activation of the adenylate cyclase pathway in the brain of grasshoppers.

A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria.

Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye.

DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae.

The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones.

Spatial-temporal imaging of bacterial infection and antibiotic response in intact animals.

Kinetic trapping of DNA by transcription factor IIIB.

Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.

Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.

The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti.

Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid.

Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates.

Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling.

Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice.

Functional activity and role of cation-efflux family members in Ni hyperaccumulation in Thlaspi goesingense.

UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53.

HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme.

Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor.

Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins.

Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages.

Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase.

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems.

A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist

Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice.

Sexual dimorphism among bovine embryos in their ability to make the transition to expanded blastocyst and in the expression of the signaling molecule IFN-tau.

Old World sources of the first New World human inhabitants: a comparative craniofacial view.

Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and Vibrio.

Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB

Antisense DNAs as multisite genomic modulators identified by DNA microarray.

Structure of the gene 2.5 protein, a single-stranded DNA binding protein encoded by bacteriophage T7.

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.

SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.

Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death

A novel mammalian receptor for the evolutionarily conserved type II GnRH

Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion

Theoretical emission line ratios for [Fe III] and [Fe VII] applicable to the optical and infrared spectra of gaseous nebulae.

Transgene analysis proves mRNA trans-splicing at the complex mod(mdg4) locus in Drosophila.

Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function.

The yeast mutant vps5Δ affected in the recycling of Golgi membrane proteins displays an enhanced vacuolar $Mg^{2+}/H^{+}$ exchange activity

The active site dynamics of 4-chlorobenzoyl-CoA dehalogenase.

Phase transition between disordered and ordered foraging in Pharaoh's ants.

Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.

Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ.

Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation.

Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.

Mechanism of termination of DNA replication of Escherichia coli involves helicase-contrahelicase interaction.

Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers.

A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity.

Bat predation on nocturnally migrating birds.

Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization.

Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase.

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor.

DNA/DNA hybridization to microarrays reveals gene-specific differences between closely related microbial genomes.

Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase

Exploring the transcriptome of the malaria sporozoite stage

Gene expression profiling of clear cell renal cell carcinoma: gene identification and prognostic classification.

Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.

Functional analysis of the LACERATA gene of Arabidopsis provides evidence for different roles of fatty acid omega -hydroxylation in development.

Crossmodal binding of fear in voice and face.

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD.

Periodic perturbations in Shaker $K^{+}$ channel gating kinetics by deletions in the S3–S4 linker

Identification of a family of Fc receptor homologs with preferential B cell expression.

Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.

DsbC activation by the N-terminal domain of DsbD.

The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells.

Hepatitis C virus replication is directly inhibited by IFN-α in a full-length binary expression system

Formation of a selenium-substituted rhodanese by reaction with selenite and glutathione: possible role of a protein perselenide in a selenium delivery system.

Essential role of Drosophila Hdac1 in homeotic gene silencing.

Neural agrin controls acetylcholine receptor stability in skeletal muscle fibers.

Type I topoisomerase activity is required for proper chromosomal segregation in Escherichia coli.

Mitochondria play no roles in Mn(II)-induced apoptosis in HeLa cells.

Heart regeneration in adult MRL mice.

Arousal effect of orexin A depends on activation of the histaminergic system

Interchain hydrogen-bonding interactions may facilitate translocation of $K^{+}$ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry

Aggregate sound velocities and acoustic Grüneisen parameter of iron up to 300 GPa and 1,200 K.

Quantum optical implementation of Grover's algorithm.

Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity

Propagating conformational changes over long (and short) distances in proteins.

A Drosophila PIAS homologue negatively regulates stat92E.

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.

Apaf-1 deficiency and neural tube closure defects are found in fog mice.

Evaluating hypotheses of basal animal phylogeny using complete sequences of large and small subunit rRNA.

An Eulerian path approach to DNA fragment assembly.

Treatment of spinal muscular atrophy by sodium butyrate.

An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer.

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease.

A new recommended dietary allowance of vitamin C for healthy young women.

A neurohistochemical blueprint for pain-induced loss of appetite.

Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats.

Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors.

A cranium for the earliest Europeans: phylogenetic position of the hominid from Ceprano, Italy.

Year: 2001 Volume: 98 Issue: 16

Year: 2001 Volume: 98 Issue: 15

Year: 2001 Volume: 98 Issue: 14

Year: 2001 Volume: 98 Issue: 13

Year: 2001 Volume: 98 Issue: 12

Year: 2001 Volume: 98 Issue: 11

Year: 2001 Volume: 98 Issue: 10

Year: 2001 Volume: 98 Issue: 9

Year: 2001 Volume: 98 Issue: 8

Year: 2001 Volume: 98 Issue: 7

Year: 2001 Volume: 98 Issue: 6

Year: 2001 Volume: 98 Issue: 5

Year: 2001 Volume: 98 Issue: 4

Year: 2001 Volume: 98 Issue: 3

Year: 2001 Volume: 98 Issue: 2

Year: 2001 Volume: 98 Issue: 1

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	White, S. B. Lee, F. S. Yu, F. Zhao, Q.
Description	Author Affiliation: Yu F ( Department of Pathology and Laboratory Medicine, University of Pennsylvania Cancer Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.);
Abstract	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a global transcriptional regulator of the hypoxic response. Under normoxic conditions, HIF-1alpha is recognized by the von Hippel-Lindau tumor-suppressor protein (VHL), a component of an E3 ubiquitin ligase complex. This interaction thereby promotes the rapid degradation of HIF-1alpha. Under hypoxic conditions, HIF-1alpha is stabilized. We have previously shown that VHL binds in a hypoxia-sensitive manner to a 27-aa segment of HIF-1alpha, and that this regulation depends on a posttranslational modification of HIF-1alpha. Through a combination of in vivo coimmunoprecipitation assays using VHL and a panel of point mutants of HIF-1alpha in this region, as well as MS and in vitro binding assays, we now provide evidence that this modification, which occurs under normoxic conditions, is hydroxylation of Pro-564 of HIF-1alpha. The data furthermore show that this proline hydroxylation is the primary regulator of VHL binding.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Metabolism Hydroxyproline Physiology Ligases Nuclear Proteins Protein Processing, Post-Translational Proteins Transcription Factors Tumor Suppressor Proteins Ubiquitin-Protein Ligases Amino Acid Sequence Animals COS Cells Cell Hypoxia Cercopithecus Aethiops Cobalt Pharmacology HeLa Cells Hydroxylation Chemistry Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, Alpha Subunit Macromolecular Substances Molecular Sequence Data Peptide Fragments Point Mutation Proline Protein Binding Drug Effects Genetics Recombinant Fusion Proteins Transfection Von Hippel-Lindau Tumor Suppressor Protein Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in