NDLI: Mutation rates in mammalian genomes.

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Mutation rates in mammalian genomes.

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Mutation rates in mammalian genomes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Subramanian, Sankar Kumar, Sudhir
Description	Author Affiliation: Kumar S ( Department of Biology, Arizona State University, Tempe, AZ 85287-1501, USA. skumar@asu.edu);
Abstract	Knowledge of the rate of point mutation is of fundamental importance, because mutations are a vital source of genetic novelty and a significant cause of human diseases. Currently, mutation rate is thought to vary many fold among genes within a genome and among lineages in mammals. We have conducted a computational analysis of 5,669 genes (17,208 sequences) from species representing major groups of placental mammals to characterize the extent of mutation rate differences among genes in a genome and among diverse mammalian lineages. We find that mutation rate is approximately constant per year and largely similar among genes. Similarity of mutation rates among lineages with vastly different generation lengths and physiological attributes points to a much greater contribution of replication-independent mutational processes to the overall mutation rate. Our results suggest that the average mammalian genome mutation rate is 2.2 x 10(-9) per base pair per year, which provides further opportunities for estimating species and population divergence times by using molecular clocks.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genome Mammals Genetics Mutation Animals Databases, Genetic Evolution, Molecular Genome, Human Mice Point Mutation Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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