NDLI: CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.

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CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.

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CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Salgia, Ravi Tibaldi, Elena V. Reinherz, Ellis L.
Description	Author Affiliation: Tibaldi EV ( Laboratory of Immunobiology, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.);
Abstract	Dynamic binding between CD2 and CD58 counter-receptors on opposing cells optimizes immune recognition through stabilization of cell-cell contact and juxtaposition of surface membranes at a distance suitable for T cell receptor-ligand interaction. Digitized time-lapse differential interference contrast and immunofluorescence microscopy on living cells now show that this binding also induces T cell polarization. Moreover, CD2 can facilitate motility of T cells along antigen-presenting cells via a movement referred to as scanning. Both activated CD4 and CD8 T cells are able to scan antigen-presenting cells surfaces in the absence of cognate antigen. Scanning is critically dependent on T cell beta-integrin function, as well as myosin light chain kinase. More importantly, surface CD2 molecules rapidly redistribute on interaction with a cellular substratum, resulting in a 100-fold greater CD2 density in the uropod versus the leading edge. In contrast, no redistribution is observed for CD11a/CD18 or CD45. Molecular compartmentalization of CD2, T cell receptor, and lipid rafts within the uropod prearranges the cellular activation machinery for subsequent immune recognition. This 'presynapse' formation on primed T cells will likely facilitate the antigen-dependent recognition capability required for efficient immune surveillance.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, CD2 Immunology Immunologic Surveillance Lymphocyte Activation T-Lymphocytes Antigens, CD Cytoplasm Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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