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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wielockx, Ben Libert, Claude Guénet, Jean-louis Staelens, Jan Puimège, Leen Van Roy, Frans |
| Description | Author Affiliation: Staelens J ( Department of Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, K. L. Ledeganckstraat 35, B-9000 Ghent, Belgium.); |
| Abstract | Tumor necrosis factor (TNF) is a central mediator in lethal shock and an interesting cytokine for anticancer therapy. To inhibit TNF-induced lethal shock, it is important to identify protective genes. Here we demonstrate that the SPRET/Ei mouse strain, derived from Mus spretus, exhibits an extremely dominant resistance to TNF-induced lethal inflammation. An interspecific backcross experiment revealed that the TNF hyporesponse is linked to loci on chromosomes 2, 6, and 11. Treatment of inoculated tumors with TNF and IFN-gamma leads to regression and a highly reduced toxicity in (C57BL/6 x SPRET/Ei)F(1) mice. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Shock Etiology Tumor Necrosis Factor-alpha Toxicity Animals Cell Death Drug Effects Drug Resistance Fibroblasts Cytology Genetic Linkage Interferon-gamma Therapeutic Use Interleukin-6 Biosynthesis Macrophages, Peritoneal Immunology Melanoma, Experimental Drug Therapy Mice Mice, Inbred BALB C Mice, Inbred C57BL Muridae Recombinant Proteins Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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