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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Zhi-yong Gale, Nick W. Hu, Tian-jing Cooper, Margaret Yue, Yong Yue, Xin Crockett, David P. Yancopoulos, George D. Tessarollo, Lino Zhou, Renping Blair-flynn, Jan |
| Description | Author Affiliation: Yue Y ( Department of Chemical Biology, College of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.); |
| Abstract | Topographic mapping of axon terminals is a general principle of neural architecture that underlies the interconnections among many neural structures. The Eph family tyrosine kinase receptors and their ligands, the ephrins, have been implicated in the formation of topographic projection maps. We show that multiple Eph receptors and ligands are expressed in the hippocampus and its major subcortical projection target, the lateral septum, and that expression of a truncated Eph receptor in the mouse brain results in a pronounced alteration of the hippocamposeptal topographic map. Our observations provide strong support for a critical role of Eph family guidance factors in regulating ontogeny of hippocampal projections. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Axons Physiology Fetal Proteins Metabolism Hippocampus Receptor Protein-Tyrosine Kinases Animals COS Cells Cercopithecus Aethiops Ephrin-A2 Ephrin-A3 Ephrin-A5 Biosynthesis Gene Expression Ligands Membrane Proteins Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Genetics Receptor, EphA4 Receptor, EphA5 Receptor, EphA7 Transcription Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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