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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Speed, Terence P. Symons, R. C. Andrew Gerondakis, Steven Fridlyand, Jane Foote, Simon J. Harris, Alan W. Daly, Mark J. Cook, Wendy D. |
| Description | Author Affiliation: Symons RC ( The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.); |
| Abstract | There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F2 hybrid mice, and have mapped at least six loci on chromosomes 2, 4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor susceptibility in male and female mice. Survival in females may be largely controlled by a pair of interacting loci on chromosomes 2 and 17. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation, Neoplastic Physiology Genes, Abl Genetic Predisposition To Disease Plasmacytoma Genetics Algorithms Animals Crosses, Genetic Disease Models, Animal Genetic Linkage Genotype Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Morbidity Epidemiology Mortality Survival Analysis Time Factors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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