NDLI: Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme

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Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme

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Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Woodson, Sarah A. Masquida, Benoît Westhof, Eric Rangan, Prashanth
Description	Author Affiliation: Rangan P ( T. C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.);
Abstract	Compact but non-native intermediates have been implicated in the hierarchical folding of several large RNAs, but there is little information on their structure. In this article, ribonuclease and hydroxyl radical cleavage protection assays showed that base pairing of core helices stabilize a compact state of a small group I ribozyme from Azoarcus pre-tRNA(ile). Base pairing of the ribozyme core requires 10-fold less Mg(2+) than stable tertiary interactions, indicating that assembly of helices in the catalytic core represents a distinct phase that precedes the formation of native tertiary structure. Tertiary folding occurs in <100 ms at 37 degrees C. Such rapid folding is unprecedented among group I ribozymes and illustrates the association between structural complexity and folding time. A 3D model of the Azoarcus ribozyme was constructed by identifying homologous sequence motifs in rRNA. The model reveals distinct structural features, such as a large interface between the P4-P6 and P3-P9 domains, that may explain the unusual stability of the Azoarcus ribozyme and the cooperativity of folding.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Azoarcus Enzymology Protein Folding RNA, Catalytic Chemistry Introns Magnesium Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Protein Structure, Tertiary Genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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