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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lintermann, Ruth Roth, Guenther E. Gierl, Mathias S. Korge, Guenter Vollborn, Lars Meise, Martin |
| Description | Author Affiliation: Roth GE ( Institut für Biologie, Freie Universität Berlin, Arnimallee 7, 14195 Berlin, Germany. groth@genetik.fu-berlin.de); |
| Abstract | Human metastatic lymph node 64 (MLN64) is a transmembrane protein that shares homology with the cholesterol-binding vertebrate steroid acute regulatory protein (StAR)-related lipid transfer domain (START) and is involved in cholesterol traffic and steroid synthesis. We identified a Drosophila melanogaster gene whose putative protein product shows extensive homology with MLN64 and that we name Start1 (FlyBase CG3522). The putative Start1 protein, derived from Start1 cDNA sequences, contains an additional 122 aa of unknown function within the StAR-related lipid transfer domain. Similar inserts seem to exist in the Start1 homologues of Drosophila pseudoobscura and Anopheles gambiae, but not in the homologous protein of the urochordate Ciona intestinalis. Immunostaining using an insert-specific antibody confirms the presence of the insert in the cytoplasm. Whereas RT-PCR data indicate that Start1 is expressed ubiquitously, RNA in situ hybridizations demonstrate its overexpression in prothoracic gland cells, where ecdysteroids are synthesized from cholesterol. Transcripts of Start1 are detectable in embryonic ring gland progenitor cells and are abundant in prothoracic glands of larvae showing wave-like expression during larval stages. In adults, Start1 is expressed in nurse cells of the ovary. These observations are consistent with the assumption that Start1 plays a key role in the regulation of ecdysteroid synthesis. Vice versa, the expression of Start1 itself seems to depend on ecdysone, as in the ecdysone-deficient mutant ecd-1, Start1 expression is severely reduced. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 101 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2004-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cholesterol Metabolism Drosophila Proteins Genetics Drosophila Melanogaster Ecdysteroids Biosynthesis Membrane Transport Proteins Amino Acid Sequence Animals Biological Transport Cloning, Molecular Chemistry Ecdysone Physiology Gene Expression Regulation In Situ Hybridization Molecular Sequence Data Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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