NDLI: Postsynaptic N-methyl-d-aspartate receptor function requires α-neurexins

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2004 Volume: 101 Issue: 42

Year: 2004 Volume: 101 Issue: 41

Year: 2004 Volume: 101 Issue: 40

Year: 2004 Volume: 101 Issue: 39

Year: 2004 Volume: 101 Issue: 38

Year: 2004 Volume: 101 Issue: 37

Year: 2004 Volume: 101 Issue: 36

Year: 2004 Volume: 101 Issue: 35

Year: 2004 Volume: 101 Issue: 34

Year: 2004 Volume: 101 Issue: 33

Year: 2004 Volume: 101 Issue: 32

Year: 2004 Volume: 101 Issue: 31

Year: 2004 Volume: 101 Issue: 30

Year: 2004 Volume: 101 Issue: 29

Year: 2004 Volume: 101 Issue: 28

Year: 2004 Volume: 101 Issue: 27

Year: 2004 Volume: 101 Issue: 26

Year: 2004 Volume: 101 Issue: 25

Year: 2004 Volume: 101 Issue: 24

Year: 2004 Volume: 101 Issue: 23

Year: 2004 Volume: 101 Issue: 22

Year: 2004 Volume: 101 Issue: 21

Year: 2004 Volume: 101 Issue: 20

Year: 2004 Volume: 101 Issue: 19

Year: 2004 Volume: 101 Issue: 18

Year: 2004 Volume: 101 Issue: 17

Year: 2004 Volume: 101 Issue: 16

Year: 2004 Volume: 101 Issue: 15

Year: 2004 Volume: 101 Issue: 14

Year: 2004 Volume: 101 Issue: 12

Year: 2004 Volume: 101 Issue: 11

Year: 2004 Volume: 101 Issue: 10

Year: 2004 Volume: 101 Issue: 9

Year: 2004 Volume: 101 Issue: 8

Teaching bacteria a new language.

Functional analysis of each blue light receptor, cry1, cry2, phot1, and phot2, by using combinatorial multiple mutants in Arabidopsis.

Membrane and acto-myosin tension promote clustering of adhesion proteins.

Engineering Escherichia coli for efficient conversion of glucose to pyruvate

Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics

Probing the antibody-catalyzed water-oxidation pathway at atomic resolution

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo.

Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase.

Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes.

Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family.

Functional bacteriorhodopsin is efficiently solubilized and delivered to membranes by the chaperonin GroEL.

The elongation of yeast prion fibers involves separable steps of association and conversion.

From conversion to aggregation: protofibril formation of the prion protein.

Design of artificial cell-cell communication using gene and metabolic networks.

Protein structure prediction for the male-specific region of the human Y chromosome.

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.

Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo.

Agonist-induced $Ca^{2+}$ entry determined by inositol 1,4,5-trisphosphate recognition

RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates $Ca^{2+}$ release

Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions.

The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.

The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.

The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis.

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.

Reactivation of developmental programs: the cAMP-response element-binding protein pathway is involved in hydra head regeneration.

High genetic variability and low local diversity in a population of arbuscular mycorrhizal fungi.

Association between climate variability and malaria epidemics in the East African highlands.

Stabilizing selection on genomic divergence in a wild fish population.

Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping.

Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.

Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition.

Evolutionary comparisons suggest many novel cAMP response protein binding sites in Escherichia coli.

Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells.

Interplay between antibacterial effectors: a macrophage antimicrobial peptide impairs intracellular Salmonella replication.

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood.

The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.

Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation.

Analysis of intergenic transcription in the human IL-4/IL-13 gene cluster.

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.

Extrapancreatic insulin-producing cells in multiple organs in diabetes.

Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals.

Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1).

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.

Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.

Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3

An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory.

Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia.

Genetic and biophysical studies of diphtheria toxin repressor (DtxR) and the hyperactive mutant DtxR(E175K) support a multistep model of activation.

The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.

Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity.

The Vibrio cholerae chitin utilization program.

The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes.

Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association.

Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: molecular epidemiology and genome evolution.

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.

Unexpected $Ca^{2+}-binding$ properties of synaptotagmin 9

Topographic specificity of functional connections from hippocampal CA3 to CA1.

Optical imaging of visually evoked responses in prosimian primates reveals conserved features of the middle temporal visual area.

Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells.

Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner.

The human olfactory receptor gene family.

Prostaglandin $E_{2}-increased$ thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition

Potentiation of NMDA receptor currents by dopamine $D_{1}$ receptors in prefrontal cortex

Radixin is a constituent of stereocilia in hair cells.

Postsynaptic N-methyl-d-aspartate receptor function requires α-neurexins

Identification of a developmentally regulated striatum-enriched zinc-finger gene, Nolz-1, in the mammalian brain.

S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity.

Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G

Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission

Nongenomic stimulation of vacuolar $H^{+}-ATPases$ in intercalated renal tubule cells by aldosterone

Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria.

Year: 2004 Volume: 101 Issue: 7

Year: 2004 Volume: 101 Issue: 6

Year: 2004 Volume: 101 Issue: 5

Year: 2004 Volume: 101 Issue: 4

Year: 2004 Volume: 101 Issue: 3

Year: 2004 Volume: 101 Issue: 2

Year: 2004 Volume: 101 Issue: Suppl 2

Year: 2004 Volume: 101 Issue: 1

Year: 2004 Volume: 101 Issue: Suppl 1

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Postsynaptic N-methyl-d-aspartate receptor function requires α-neurexins

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Südhof, Thomas C. Gottmann, Kurt Kattenstroth, Gunnar Tantalaki, Evangelia Missler, Markus
Description	Author Affiliation: Kattenstroth G ( Lehrstuhl für Zellphysiologie, Ruhr-Universität, D-44780 Bochum, Germany.);
Abstract	Alpha-neurexins are neuron-specific cell-surface molecules that are essential for the functional organization of presynaptic Ca2+ channels and release sites. We have now examined postsynaptic glutamate receptor function in alpha-neurexin knockout (KO) mice by using whole-cell recordings in cultured neocortical slices. Unexpectedly, we find that alpha-neurexins are required for normal activity of N-methyl-D-aspartate (NMDA)- but not alpha-amino-3-hydroxy-5-methyl-4-isoxyzolepropionic acid (AMPA)-type glutamate receptors. In alpha-neurexin-deficient mice, the ratio of NMDA- to AMPA-receptor currents, recorded as evoked synaptic responses, was diminished approximately 50%. Furthermore, the NMDA-receptor-dependent component of spontaneous synaptic miniature responses was reduced approximately 50%, whereas the AMPA-receptor-dependent component was unaffected. No alterations in the levels of NMDA- or AMPA-receptor proteins were detected. These results suggest that alpha-neurexins are required to maintain normal postsynaptic NMDA-receptor function. The decrease in NMDA-receptor activity in alpha-neurexin-deficient synapses could be due to a transsynaptic effect on the postsynaptic neuron (i.e., alpha-neurexins on the presynaptic inputs guide postsynaptic NMDA-receptor function) or to a cell-autonomous postsynaptic effect of alpha-neurexins on NMDA-receptor activity. To distinguish between these two possibilities, we cocultured WT GFP-labeled neurons with neocortical slices from alpha-neurexin-deficient or control mice. No difference was found between WT neurons innervated by inputs that contained or lacked alpha-neurexins, indicating that the absence of presynaptic alpha-neurexins alone does not depress postsynaptic NMDA-receptor function. Our data suggest that, in addition to the previously described presynaptic impairments, loss of alpha-neurexins induces postsynaptic changes by a cell-autonomous mechanism.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	101
Language	English
Publisher	National Academy of Sciences
Publisher Date	2004-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Neocortex Physiology Nerve Tissue Proteins Neurons Receptors, N-Methyl-D-Aspartate Synapses Animals Cell Culture Techniques Gene Deletion Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout N-Methylaspartate Pharmacology Drug Effects Genetics Cytology Receptors, AMPA Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in