NDLI: Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2004 Volume: 101 Issue: 42

Year: 2004 Volume: 101 Issue: 41

Year: 2004 Volume: 101 Issue: 40

Year: 2004 Volume: 101 Issue: 39

Year: 2004 Volume: 101 Issue: 38

Year: 2004 Volume: 101 Issue: 37

Year: 2004 Volume: 101 Issue: 36

Year: 2004 Volume: 101 Issue: 35

Year: 2004 Volume: 101 Issue: 34

Year: 2004 Volume: 101 Issue: 33

Year: 2004 Volume: 101 Issue: 32

Year: 2004 Volume: 101 Issue: 31

Year: 2004 Volume: 101 Issue: 30

Year: 2004 Volume: 101 Issue: 29

Year: 2004 Volume: 101 Issue: 28

Year: 2004 Volume: 101 Issue: 27

Year: 2004 Volume: 101 Issue: 26

Year: 2004 Volume: 101 Issue: 25

Year: 2004 Volume: 101 Issue: 24

Year: 2004 Volume: 101 Issue: 23

Year: 2004 Volume: 101 Issue: 22

Year: 2004 Volume: 101 Issue: 21

Year: 2004 Volume: 101 Issue: 20

Year: 2004 Volume: 101 Issue: 19

Year: 2004 Volume: 101 Issue: 18

Year: 2004 Volume: 101 Issue: 17

Year: 2004 Volume: 101 Issue: 16

Year: 2004 Volume: 101 Issue: 15

Year: 2004 Volume: 101 Issue: 14

Year: 2004 Volume: 101 Issue: 12

Year: 2004 Volume: 101 Issue: 11

Year: 2004 Volume: 101 Issue: 10

Year: 2004 Volume: 101 Issue: 9

Astrocyte-mediated activation of neuronal kainate receptors

Expression of an active tobacco mitogen-activated protein kinase kinase kinase enhances freezing tolerance in transgenic maize

Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.

Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus

Integrating the genotype and phenotype in hominid paleontology.

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.

Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus.

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.

Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering.

Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum $Ca^{2+}-ATPase$ assists in catalysis of $E_{2}/E_{2}P$ partial reactions

Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 101 Issue: 9)

Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis.

Correspondence of presaccadic activity in the monkey primary visual cortex with saccadic eye movements.

Comparisons of pollen coat genes across Brassicaceae species reveal rapid evolution by repeat expansion and diversification.

Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease.

ADP reduces the oxygen-binding affinity of a sensory histidine kinase, FixL: the possibility of an enhanced reciprocating kinase reaction.

Fluorescence correlation spectroscopy with high-order and dual-color correlation to probe nonequilibrium steady states.

Imprint of evolution on protein structures.

Identification of critical residues in GlnB for its activation of NifA activity in the photosynthetic bacterium Rhodospirillum rubrum.

Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.

The vortex patch problem for the surface quasi-geostrophic equation.

Activation of the Wnt signaling pathway in chronic lymphocytic leukemia.

Adaptive role of increased frequency of polypurine tracts in mRNA sequences of thermophilic prokaryotes.

Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled γ-phosphate-linked GTP analogs

The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids.

Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation.

Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex.

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

FRIGIDA-related genes are required for the winter-annual habit in Arabidopsis.

Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron efflux

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.

Portability and fidelity of RNA-repair systems.

Gene transfer in the evolution of parasite nucleotide biosynthesis.

Revealing modularity and organization in the yeast molecular network by integrated analysis of highly heterogeneous genomewide data.

Trends between gene content and genome size in prokaryotic species with larger genomes.

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis

Categorization in the monkey hippocampus: a possible mechanism for encoding information into memory.

Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.

Molecular chaperones function as steroid receptor nuclear mobility factors.

On the role of RNA silencing in the pathogenicity and evolution of viroids and viral satellites.

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.

Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate

Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling.

Serum leptin level is a regulator of bone mass.

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts.

Cellular protein is the source of cross-priming antigen in vivo.

The nonconserved wrapping of conserved protein folds reveals a trend toward increasing connectivity in proteomic networks.

Transition state stabilization by general acid catalysis, water expulsion, and enzyme reorganization in Medicago savita chalcone isomerase.

Almost sharp fronts for the surface quasi-geostrophic equation.

Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation.

Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.

Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.

Induction and transmission of Bacillus thuringiensis tolerance in the flour moth Ephestia kuehniella.

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.

Solvation in protein folding analysis: Combination of theoretical and experimental approaches

Crystal structure of the complex between thrombin and the central 'E' region of fibrin.

Two discriminatory binding sites in the Escherichia coli replication origin are required for DNA strand opening by initiator DnaA-ATP.

Cardiovascular fitness, cortical plasticity, and aging.

Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450.

Role for neuronal insulin resistance in neurodegenerative diseases.

RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells.

From The Cover: The X3LYP extended density functional for accurate descriptions of nonbond interactions, spin states, and thermochemical properties.

NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.

Global analysis of Escherichia coli RNA degradosome function using DNA microarrays.

Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists.

Determinants of liposome fusion mediated by synaptic SNARE proteins.

Defining and identifying communities in networks.

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture.

Intrachromosomal excision of a hybrid Ds element induces large genomic deletions in Arabidopsis.

Engineering biological structures of prescribed shape using self-assembling multicellular systems.

TLR2 is expressed on activated T cells as a costimulatory receptor.

CIS display: In vitro selection of peptides from libraries of protein-DNA complexes.

Transportin2 functions as importin and mediates nuclear import of HuR.

Pseudomonas syringae pv. tomato cells encounter inhibitory levels of water stress during the hypersensitive response of Arabidopsis thaliana.

When astrocytes signal, kainate receptors respond.

Expression of functional receptors by the human gamma-aminobutyric acid A gamma 2 subunit.

Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade.

Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury.

Two routes to emotional memory: distinct neural processes for valence and arousal.

Identification of a target RNA motif for RNA-binding protein HuR.

Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.

Whole-genome annotation by using evidence integration in functional-linkage networks.

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.

Alcohol inhibits luteinizing hormone-releasing hormone release by activating the endocannabinoid system.

Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid.

Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.

Bdelloid rotifers revisited.

Metallic single-walled silicon nanotubes.

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.

Differential utilization of upstream AUGs in the β-secretase mRNA suggests that a shunting mechanism regulates translation

Stereochemistry in self-assembled encapsulation complexes: constellational isomerism.

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro.

Plasma membrane localization signals in the light chain of botulinum neurotoxin.

Year: 2004 Volume: 101 Issue: 8

Year: 2004 Volume: 101 Issue: 7

Year: 2004 Volume: 101 Issue: 6

Year: 2004 Volume: 101 Issue: 5

Year: 2004 Volume: 101 Issue: 4

Year: 2004 Volume: 101 Issue: 3

Year: 2004 Volume: 101 Issue: 2

Year: 2004 Volume: 101 Issue: Suppl 2

Year: 2004 Volume: 101 Issue: 1

Year: 2004 Volume: 101 Issue: Suppl 1

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carreira, Aura Mateu, Mauricio G. Riolobos, Laura Reguera, Juan Almendral, José María
Description	Author Affiliation: Reguera J ( Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.);
Abstract	Twenty-eight amino acid residues involved in most noncovalent interactions between trimeric protein subunits in the capsid of the parvovirus minute virus of mice were truncated individually to alanine, and the effects on capsid assembly, thermostability, and conformation were analyzed. Only seven side chains were essential for protein subunit recognition. These side chains virtually corresponded with those that either buried a large hydrophobic surface on trimer association or formed buried intertrimer hydrogen bonds or salt bridges. The seven residues are evolutionarily conserved, and they define regularly spaced spots on a thin equatorial belt surrounding each trimer. Truncation of the many side chains that were dispensable for assembly, including those participating in solvent-accessible polar interactions, did not substantially affect capsid thermostability either. However, the interfacial residues located at the base of the pores delineating the capsid five-fold axes participated in a heat-induced conformational rearrangement associated with externalization of the capsid protein N terminus, and they were needed for infectivity. Thus, at the subunit interfaces of this model virus capsid, only key residues involved in the strongest interactions are critical for assembly and stability, but additional residues fulfill other important biological roles.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	101
Language	English
Publisher	National Academy of Sciences
Publisher Date	2004-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amino Acids Chemistry Capsid Proteins Minute Virus Of Mice Amino Acid Substitution Animals Binding Sites Cell Line Mice Pathogenicity Models, Molecular Mutagenesis, Site-Directed Protein Conformation Recombinant Proteins Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in