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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Choi, Han-ho Koh, Gou Young Kim, Won Lee, Gyun Min Lee, Hyuek Jong Kammerer, Richard A. Yasunaga, Kunio Kim, Kyung-tae Kim, Sung Hyun Cho, Chung-hyun Park, Sung Kwang |
| Description | Author Affiliation: Cho CH ( Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.); |
| Abstract | Radiation therapy is a widely used cancer treatment, but it causes side effects even when localized radiotherapy is used. Extensive apoptosis of microvascular endothelial cells of the lamina propria is the primary lesion initiating intestinal radiation damage after abdominal radiation therapy. Many in vitro studies suggest that angiopoietin-1 (Ang1) has potential therapeutic applications in enhancing endothelial cell survival. For in vivo use, we developed a soluble, stable, and potent Ang1 variant, COMP-Ang1. COMP-Ang1 is more potent than native Ang1 in phosphorylating the Tie2 receptor in lung endothelial cells in vivo. Interestingly, COMP-Ang1 administered i.v. was mainly localized to microvascular endothelial cells of the intestinal villi and lung but not to microvascular endothelial cells of the liver. In irradiated mice, i.v. COMP-Ang1 protected against radiation-induced apoptosis in microcapillary endothelial cells of the intestinal villi and prolonged survival. Thus, COMP-Ang1 could be used as a therapeutic protein for specific protection against endothelial cell injury. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 15 |
| Volume Number | 101 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2004-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Angiopoietin-1 Genetics Pharmacology Apoptosis Drug Effects Radiation Effects Endothelium, Vascular Extracellular Matrix Proteins Glycoproteins Radiation-Protective Agents Animals Capillaries Cytology Injections, Intravenous Intestinal Mucosa Ultrastructure Lung Metabolism Matrilin Proteins Mice Mice, Inbred Strains Phosphorylation Radiation Injuries Prevention & Control Receptor, TIE-2 Recombinant Proteins Survival Analysis Tissue Distribution Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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