NDLI: The neocortical microcircuit as a tabula rasa.

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The neocortical microcircuit as a tabula rasa.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Markram, Henry Kalisman, Nir Silberberg, Gilad
Description	Author Affiliation: Kalisman N ( Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.);
Abstract	The neocortex has a high capacity for plasticity. To understand the full scope of this capacity, it is essential to know how neurons choose particular partners to form synaptic connections. By using multineuron whole-cell recordings and confocal microscopy we found that axons of layer V neocortical pyramidal neurons do not preferentially project toward the dendrites of particular neighboring pyramidal neurons; instead, axons promiscuously touch all neighboring dendrites without any bias. Functional synaptic coupling of a small fraction of these neurons is, however, correlated with the existence of synaptic boutons at existing touch sites. These data provide the first direct experimental evidence for a tabula rasa-like structural matrix between neocortical pyramidal neurons and suggests that pre- and postsynaptic interactions shape the conversion between touches and synapses to form specific functional microcircuits. These data also indicate that the local neocortical microcircuit has the potential to be differently rewired without the need for remodeling axonal or dendritic arbors.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	102
Language	English
Publisher	National Academy of Sciences
Publisher Date	2005-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Neocortex Physiology Neurons Animals Axons Ultrastructure Dendrites Electrophysiology Imaging, Three-Dimensional Microscopy, Confocal Cytology Nerve Regeneration Rats, Wistar Synapses Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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