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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Van Sloun, Petra Schnütgen, Frank Floss, Thomas Chambon, Pierre Seisenberger, Claudia Hansen, Jens Ghyselinck, Norbert B. Ruiz, Patricia De-zolt, Silke Hollatz, Melanie Wurst, Wolfgang Von Melchner, Harald Altschmied, Joachim |
| Description | Author Affiliation: Schnütgen F ( Department of Molecular Hematology, University of Frankfurt Medical School, 60590 Frankfurt am Main, Germany.); |
| Abstract | A type of retroviral gene trap vectors has been developed that can induce conditional mutations in most genes expressed in mouse embryonic stem (ES) cells. The vectors rely on directional site-specific recombination systems that can repair and re-induce gene trap mutations when activated in succession. After the gene traps are inserted into the mouse genome, genetic mutations can be produced at a particular time and place in somatic cells. In addition to their conditional features, the vectors create multipurpose alleles amenable to a wide range of post-insertional modifications. Here we have used these directional recombination vectors to assemble the largest library of ES cell lines with conditional mutations in single genes yet assembled, presently totaling 1,000 unique genes. The trapped ES cell lines, which can be ordered from the German Gene Trap Consortium, are freely available to the scientific community. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Alleles Genes Genetics Genome Genomics Mice Stem Cells Metabolism Animals Blotting, Northern Blotting, Western Cell Line Computational Biology Embryo, Mammalian Cytology Genetic Vectors Mutagenesis, Site-Directed Mutation Polymerase Chain Reaction Retroviridae Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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