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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Claparols, Catherine Benoit-vical, Françoise Meunier, Bernard Robert, Anne |
| Description | Author Affiliation: Robert A ( Laboratoire de Chimie de Coordination du Centre National de la Recherche Scientifique, 205 Route de Narbonne, 31077 Toulouse Cedex 4, France. arobert@lcc-toulouse.fr); |
| Abstract | Heme alkylation by the antimalarial drug artemisinin is reported in vivo, within infected mice that have been treated at pharmacologically relevant doses. Adducts resulting from the alkylation of heme by the drug were characterized in the spleen of treated mice, and their glucuroconjugated derivatives were present in the urine. Because these heme-artemisinin adducts were not observed in noninfected mice, this report confirms that the alkylating activity of this antimalarial drug is related to the presence of the parasite in infected animals. The identification of heme-artemisinin adducts in mice should be considered as the signature of the alkylation capacity of artemisinin in vivo. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 38 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antimalarials Artemisinins Heme Chemistry Malaria Plasmodium Sesquiterpenes Spleen Alkylation Animals Administration & Dosage Analogs & Derivatives Metabolism Drug Therapy Urine Mice Parasitology Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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