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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bui, Huynh-hoa Peters, Bjoern Pasquetto, Valerie Kos, Ferdynand Palmore, Tara Sette, Alessandro Oseroff, Carla Grey, Howard M. Yewdell, Jonathan W. Glenn, Jean Sidney, John Tscharke, David C. Southwood, Scott Bennink, Jack R. |
| Description | Author Affiliation: Oseroff C ( La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA.); |
| Abstract | We have analyzed by ex vivo ELISPOT the anti-vaccinia cytotoxic T lymphocyte responses of peripheral blood mononuclear cells from humans vaccinated with Dryvax vaccine. More than 6,000 peptides from 258 putative vaccinia ORFs predicted to bind the common molecules of the HLA A1, A2, A3, A24, B7, and B44 supertypes were screened with peripheral blood mononuclear cells of 31 vaccinees. A total of 48 epitopes derived from 35 different vaccinia antigens were identified, some of which (B8R, D1R, D5R, C10L, C19L, C7L, F12, and O1L) were recognized by multiple donors and contain multiple epitopes recognized in the context of different HLA types. The antigens recognized tend to be >100 residues in length and are expressed predominantly in the early phases of infection, although some late antigens were also recognized. Viral genome regulation and virulence factor were recognized most frequently, whereas few structural proteins were immunogenic. Finally, most epitopes were highly conserved among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting their potential use in vaccine and diagnostic applications. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Viral Immunology Epitopes, T-Lymphocyte HLA Antigens Metabolism Histocompatibility Antigens Class I T-Lymphocytes, Cytotoxic Vaccinia Virus Vaccinia Viral Proteins Amino Acid Sequence Gene Expression Regulation, Viral Genes, Viral Genetics Molecular Sequence Data Peptides Blood Smallpox Prevention & Control Smallpox Vaccine Therapeutic Use Vaccination Virology Pathogenicity Virulence Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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