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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Xi Andzelm, Milena M. Kopcow, Hernan D. Allan, David S. J. Rybalov, Basya Strominger, Jack L. Ge, Baoxue |
| Description | Author Affiliation: Kopcow HD ( Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. hkopcow@fas.harvard.edu); |
| Abstract | In early pregnancy invading fetal trophoblasts encounter abundant maternal decidual natural killer cells (dNK). dNK express perforin, granzymes A and B and the activating receptors NKp30, NKp44, NKp46, NKG2D, and 2B4 as well as LFA-1. Even though they are granular and express the essential molecules required for lysis, fresh dNK displayed very reduced lytic activity on classical MHC I negative targets K562 and 721.221, approximately 15% of that of peripheral NK cells. dNK formed conjugates and activating immune synapses with 721.221 and K562 cells in which CD2, LFA-1 and actin were polarized toward the contact site. However, in contrast to peripheral NK cells, they failed to polarize their microtubule organizing centers and perforin-containing granules to the synapse, accounting for their lack of cytotoxicity. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 43 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cytotoxicity, Immunologic Decidua Immunology Killer Cells, Natural Lymphocyte Activation Cell Communication Cell Polarity Cytoplasmic Granules Physiology Histocompatibility Antigens Class I Ultrastructure Membrane Glycoproteins Perforin Pore Forming Cytotoxic Proteins Pregnancy Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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