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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Robinson, Alan J. Kunji, Edmund R. S. |
| Description | Author Affiliation: Robinson AJ ( Dunn Human Nutrition Unit, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom. ajr@mrc-dunn.cam.ac.uk); |
| Abstract | Mitochondrial carriers link biochemical pathways in the cytosol and mitochondrial matrix by transporting substrates across the inner mitochondrial membrane. Substrate recognition is specific for each carrier, but sequence similarities suggest the carriers have similar structures and mechanisms of substrate translocation. By considering conservation of amino acids, distance and chemical constraints, and by modeling family members on the known structure of the ADP/ATP translocase, we have identified a common substrate binding site. It explains substrate selectivity and proton coupling and provides a mechanistic link to carrier opening by substrate-induced perturbation of the salt bridges that seal the pathway to and from the mitochondrial matrix. It enables the substrate specificity of uncharacterized mitochondrial carriers to be predicted. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carrier Proteins Chemistry Mitochondrial ADP, ATP Translocases Mitochondrial Membrane Transport Proteins Phosphate Transport Proteins Saccharomyces Cerevisiae Proteins Amino Acid Sequence Binding Sites Cytoplasm Metabolism Guanosine Diphosphate Guanosine Triphosphate Ion Channels Membrane Proteins Mitochondrial Proteins Models, Molecular Molecular Sequence Data Saccharomyces Cerevisiae Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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