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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tada, Takashi Brockdorff, Neil Takagi, Nobuo Popova, Bilyana C. Nesterova, Tatyana B. |
| Description | Author Affiliation: Popova BC ( Developmental Epigenetics, Medical Research Council Clinical Sciences Center, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Road, London W12 ONN, United Kingdom.); |
| Abstract | X inactivation in female mammals involves transcriptional silencing of an entire chromosome in response to a cis-acting noncoding RNA, the X inactive-specific transcript (Xist). Xist can also inactivate autosomal sequences, for example, in X;autosome translocations; but here, silencing appears to be relatively inefficient. This variation has been attributed to either attenuated spreading of Xist RNA at the onset of X inactivation or inefficient maintenance of autosomal silencing. Evidence to date has favored the latter. Here, we demonstrate attenuated spreading of Xist RNA at the onset of X inactivation in the T(X;4)37H X;autosome translocation. Our findings provide direct evidence that underlying chromosome/chromatin features can disrupt spreading of the primary inactivating signal. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromosomes, Mammalian Genetics RNA, Untranslated Metabolism Translocation, Genetic X Chromosome Inactivation X Chromosome Animals Cell Line Gene Silencing Histones In Situ Hybridization, Fluorescence Long Interspersed Nucleotide Elements Lysine Mice RNA, Long Noncoding Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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