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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Morona, Renato Morona, Judy K. Paton, James C. |
| Description | Author Affiliation: Morona JK ( School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia.); |
| Abstract | The capacity of Streptococcus pneumoniae to produce capsular polysaccharide (CPS) is essential for virulence. The CPS biosynthesis proteins CpsB, CpsC, and CpsD function to regulate CPS production via tyrosine phosphorylation of CpsD. This mechanism of regulating CPS production is important for enabling S. pneumoniae to cause invasive disease. Here, we identify mutations affecting the attachment of CPS to the cell wall. These mutations were located in cpsC, such that CpsC functioned independently from CpsD tyrosine phosphorylation. These mutants produced WT levels of CPS, but were unable to cause bacteremia in mice after intranasal challenge. This finding suggests that cell-wall attachment of CPS is essential for invasive pneumococcal disease; production of WT levels of CPS alone is not sufficient. We also show that cpsB mutants, which lack the phosphotyrosine-protein phosphatase, produced less CPS than the WT strain, but attached substantially more CPS to their cell wall. Thus, the phosphorylated form of CpsD promotes attachment of CPS to the cell wall. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 22 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Wall Metabolism Pneumococcal Infections Microbiology Pathology Polysaccharides, Bacterial Streptococcus Pneumoniae Cytology Pathogenicity Animals Aspartic Acid Genetics Bacterial Proteins Cell Line, Tumor Drug Resistance, Bacterial Drug Effects Erythromycin Pharmacology Membrane Fusion Mice Mutation Protein Tyrosine Phosphatases Protein-Tyrosine Kinases Classification Tetracycline Virulence Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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