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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hammond, Kirsten J. L. Dewint, Pieter Deforce, Dieter Kronenberg, Mitchell Franki, Ann Sophie Lambrecht, Stijn Elewaut, Dirk Van Beneden, Katrien Leclercq, Georges |
| Description | Author Affiliation: Franki AS ( Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, B-9000 Ghent, Belgium.); |
| Abstract | Natural killer (NK) T cells using an invariant Valpha14 (Valpha14i) T cell receptor rearrangement form a distinct immunoregulatory T cell lineage. Several studies indicated that a NK1.1(-) Valpha14i NKT precursor cell differentiates and expands within the thymus before export to the peripheral tissues occurs. However, little is known about the signals that cause the emigration of Valpha14i NKT cells from the thymus to the periphery. Here we show that signaling of lymphotoxin (LT) alphabeta through the LTbeta receptor (LTbetaR) is indispensable for regulating peripheral but not thymic Valpha14i NKT cell numbers. Homing to and homeostatic proliferation of thymic Valpha14i NKT cells in peripheral organs, however, was not dependent on LTbetaR. Instead, our data indicate that a LTbetaR-expressing thymic stromal cell regulates the thymic emigration of Valpha14i NKT cells but not conventional T cell receptor alphabeta cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Movement Physiology Killer Cells, Natural Metabolism Lymphotoxin-alpha Membrane Proteins Signal Transduction T-Lymphocyte Subsets Thymus Gland Cytology Animals Cell Survival Liver Lymphotoxin Beta Receptor Lymphotoxin-beta Mice Mice, Inbred C57BL Mice, Knockout Pregnancy Protein Isoforms Receptors, Antigen, T-Cell Receptors, Tumor Necrosis Factor Genetics Recombinant Fusion Proteins Spleen Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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