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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vyas, Jatin M. Artavanis-tsakonas, Katerina Ploegh, Hidde L. Love, J. Christopher |
| Description | Author Affiliation: Artavanis-Tsakonas K ( Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.); |
| Abstract | The subcellular localization of the cluster of differentiation 63 (CD63) tetraspanin and its interaction with the class II MHC antigen presentation pathway were examined in the context of phagocytosis by live cell imaging, by using monomeric red fluorescent protein-tagged mouse CD63 expressed in primary bone marrow-derived cell cultures. Upon phagocytosis of Cryptococcus neoformans and polystyrene beads, CD63 was recruited selectively to C. neoformans-containing phagosomes in a MyD88-independent acidification-dependent manner. Bead-containing phagosomes, within a C. neoformans-containing cell, acidified to a lesser extent and failed to recruit CD63 to a level detectable by microscopy. CD63 recruitment to yeast phagosomes occurred independently of class II MHC and LAMP-1. These observations indicate that the composition of distinct phagosomal compartments within the same cell is determined by phagosomal cargo and may affect the outcome of antigen processing and presentation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 43 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Acids Antigens, CD Immunology Metabolism Antigens, Surface Cryptococcus Neoformans Membrane Glycoproteins Phagosomes Animals Genetics Antigens, CD63 Biological Markers Cell Line Genes, Reporter Histocompatibility Antigens Class II Hydrogen-Ion Concentration Lysosomes Mice Platelet Membrane Glycoproteins Protein Processing, Post-Translational Recombinant Fusion Proteins Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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