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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yamashita, Tomoki Uchiyama, Tsuneo Adachi, Akio Igarashi, Tatsuhiko Khamsri, Boonruang Fujita, Mikako Martin, Malcolm A. Kamada, Kazuya Hatcho, Kazuki |
| Description | Author Affiliation: Kamada K ( Department of Virology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima-shi, Tokushima 770-8503, Japan.); |
| Abstract | The narrow host range of human immunodeficiency virus type 1 (HIV-1) is caused in part by innate cellular factors such as apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) and TRIM5alpha, which restrict virus replication in monkey cells. Variant HIV-1 molecular clones containing both a 21-nucleotide simian immunodeficiency virus (SIV) Gag CA element, corresponding to the HIV-1 cyclophilin A-binding site, and the entire SIV vif gene were constructed. Long-term passage in a cynomolgus monkey lymphoid cell line resulted in the acquisition of two nonsynonymous changes in env, which conferred improved replication properties. A proviral molecular clone, derived from infected cells and designated NL-DT5R, was used to generate virus stocks capable of establishing spreading infections in the cynomolgus monkey T cell line and CD8-depleted peripheral blood mononuclear cells from five of five pig-tailed macaques and one of three rhesus monkeys. NL-DT5R, which genetically is >93% HIV-1, provides the opportunity, not possible with currently available SIV/HIV chimeric viruses, to analyze the function of multiple HIV-1 genes in a broad range of nonhuman primate species. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 45 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | HIV-1 Genetics Pathogenicity Lymphocytes Virology Macaca Animals Capsid Proteins Cell Line Cytidine Deaminase Antagonists & Inhibitors Metabolism DNA, Viral Genes, Viral Genes, Vif Physiology Molecular Sequence Data Simian Immunodeficiency Virus Virus Replication Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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