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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Casavant, Thomas L. Scheetz, Todd E. Welsh, Michael J. Ben-shahar, Yehuda Nannapaneni, Kishore |
| Description | Author Affiliation: Ben-Shahar Y ( Howard Hughes Medical Institute, and Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, IA 52242, USA.); |
| Abstract | Complex biological processes require coordinated function of many genes. One evolutionary solution to the problem of coordinately expressing functionally related genes in bacteria and nematodes is organization of genes in operons. Surprisingly, eukaryotic operons are considered rare outside the nematode lineage. In Drosophila melanogaster, we found lounge lizard (llz), which encodes a degenerin/ENaC cation channel, cotranscribed with CheB42a, a nonhomologous gene of unknown function residing <100 bp upstream. These two genes were transcribed from a single promoter as one primary transcript and were processed posttranscriptionally to generate individual mRNAs. The mechanism did not involve alternative splicing, and it differed from the trans splicing used in nematode operons. Both genes were expressed in the same tissues, and previous work suggested that both may be involved in courtship behavior. A bioinformatic approach identified numerous additional loci as potential Drosophila operons. These data reveal eukaryotic operon-like transcription of functionally related genes in Drosophila. The results also suggest that operon-based transcription may be more common in eukaryotes than previously appreciated. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Proteins Genetics Drosophila Operon RNA-Binding Proteins Ribonucleoprotein, U1 Small Nuclear Transcription, Genetic Animals Chromosome Mapping Molecular Sequence Data Promoter Regions, Genetic RNA, Messenger Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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