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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hirose, Matsumi Green, Carla B. Saigo, Kaoru Matsumoto, Ken Nagano, Mamoru Sakaki, Yoshiyuki Hoshino, Shin-ichi Kojima, Shihoko Shimada, Miyuki Shigeyoshi, Yasufumi Tei, Hajime Ui-tei, Kumiko |
| Description | Author Affiliation: Kojima S ( Laboratory of Chronogenomics, Mitsubishi Kagaku Institute of Life Sciences, Minamiooya, Machida, Tokyo, Japan.); |
| Abstract | The mammalian molecular clock is composed of feedback loops to keep circadian 24-h rhythms. Although much focus has been on transcriptional regulation, it is clear that posttranscriptional controls also play important roles in molecular circadian clocks. In this study, we found that mouse LARK (mLARK), an RNA binding protein, activates the posttranscriptional expression of the mouse Period1 (mPer1) mRNA. A strong circadian cycling of the mLARK protein is observed in the suprachiasmatic nuclei with a phase similar to that of mPER1, although the level of the Lark transcripts are not rhythmic. We demonstrate that LARK causes increased mPER1 protein levels, most likely through translational regulation and that the LARK1 protein binds directly to a cis element in the 3' UTR of the mPer1 mRNA. Alterations of mLark expression in cycling cells caused significant changes in circadian period, with mLark knockdown by siRNA resulting in a shorter circadian period, and the overexpression of mLARK1 resulting in a lengthened period. These data indicate that mLARKs are novel posttranscriptional regulators of mammalian circadian clocks. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Biological Clocks Genetics Cell Cycle Proteins Biosynthesis Gene Expression Regulation Physiology Nuclear Proteins RNA-Binding Proteins Amino Acid Sequence Animals Circadian Rhythm Mice Mice, Inbred BALB C Molecular Sequence Data NIH 3T3 Cells Period Circadian Proteins RNA Interference Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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