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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Boullin, Julian P. Chau, Ryan Poore, Kirsten R. Khan, Omar Poston, Lucilla Newman, James P. Hanson, Mark A. Green, Lucy R. Noakes, David E. Cleal, Jane K. Torrens, Christopher Hambidge, Oliver |
| Description | Author Affiliation: Cleal JK ( Institute of Developmental Sciences, University of Southampton, Tremona Road, Southampton SO16 6YD, United Kingdom.); |
| Abstract | The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit to the fetus, but the long-term effects of these adaptations may prove detrimental if nutrition in postnatal life does not match that predicted by the fetus on the basis of its prenatal environment. We tested this predictive adaptive response hypothesis with respect to CV function in sheep. We observed that a mismatch between pre- and postnatal nutrient environments induced an altered CV function in adult male sheep that was not seen when environments were similar. Sheep that received postnatal undernutrition alone had altered growth, CV function, and basal hypothalamo-pituitary-adrenal axis activity in adulthood. Prenatal undernutrition induced greater weight gain by weaning compared with the prenatal control diet, which may provide a reserve in the face of a predicted poor diet in later life. In an adequate postnatal nutrient environment (i.e., relatively mismatched), these offspring exhibited cardiac hypertrophy and altered CV function in adulthood. These data support the concept that adult CV function can be determined by developmental responses to intrauterine nutrition made in expectation of the postnatal nutritional environment, and that if these predictions are not met, the adult may be maladapted and at greater risk of CV disease. Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 22 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Aging Physiology Animals, Newborn Metabolism Cardiovascular Diseases Physiopathology Kidney Diseases Maternal Nutritional Physiological Phenomena Prenatal Exposure Delayed Effects Prenatal Nutritional Physiological Phenomena Animals Body Weight Etiology Fetus Pregnancy Premature Birth Time Factors Ultrasonography Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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