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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Minokoshi, Yasuhiko Saito, Masayuki Takeuchi, Ayako Fujimoto, Wakako Miki, Takashi Takahashi, Yoshihisa Seino, Susumu Iwanaga, Toshihiko Kimura, Kazuhiro Shiuchi, Tetsuya |
| Description | Author Affiliation: Fujimoto W ( Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.); |
| Abstract | Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1(-/-) mouse from its cohabitants induces self-starvation, sometimes leading to death, features similar to those of anorexia nervosa in humans. Interestingly, overexpression of agouti in Dmbx1(-/-) mice failed to induce aspects of the A(y)/a phenotype, including hyperphagia, obesity, and diabetes mellitus. In Dmbx1(-/-) mice, administration of agouti-related protein increased cumulative food intake for the initial 6 h but significantly decreased it over 24- and 48-h periods. In addition, Dmbx1 was shown to be expressed at embryonic day 15.5 in the lateral parabrachial nucleus, the rostral nucleus of the tractus solitarius, the dorsal motor nucleus of the vagus, and the reticular nucleus in the brainstem, all of which receive melanocortin signaling, indicating involvement of Dmbx1 in the development of the neural network for the signaling. Thus, Dmbx1 is essential for various actions of agouti-related protein and plays a role in normal regulation of energy homeostasis and behavior. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation, Developmental Intercellular Signaling Peptides And Proteins Physiology Nerve Tissue Proteins Genetics Otx Transcription Factors Agouti-Related Protein Animals Body Weight Brain Metabolism Feeding Behavior Hypothalamus Leptin Mice Mice, Transgenic Models, Biological Neuropeptides Chemistry Phenotype Time Factors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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