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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lasalle, Janine M. Hogart, Amber Thatcher, Karen N. Peddada, Sailaja Nagarajan, Raman P. Yasui, Dag H. Farnham, Peggy J. Vallero, Roxanne O. Bieda, Mark C. |
| Description | Author Affiliation: Yasui DH ( Department of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA.); |
| Abstract | Mutations in MECP2 cause the autism-spectrum disorder Rett syndrome. MeCP2 is predicted to bind to methylated promoters and silence transcription. However, the first large-scale mapping of neuronal MeCP2-binding sites on 26.3 Mb of imprinted and nonimprinted loci revealed that 59% of MeCP2-binding sites are outside of genes and that only 6% are in CpG islands. Integrated genome-wide promoter analysis of MeCP2 binding, CpG methylation, and gene expression revealed that 63% of MeCP2-bound promoters are actively expressed and that only 6% are highly methylated. These results indicate that the primary function of MeCP2 is not the silencing of methylated promoters. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 49 |
| Volume Number | 104 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2007-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation Methyl-CpG-Binding Protein 2 Metabolism Rett Syndrome Genetics Binding Sites Chromatin Immunoprecipitation CpG Islands DNA Methylation Gene Silencing Neurons Promoter Regions, Genetic Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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