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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Draghia-akli, Ruxandra Von Gegerfelt, Agneta S. Rosati, Margherita Van Rompay, Koen K. A. Valentin, Antonio Jalah, Rashmi Pavlakis, George N. Bergamaschi, Cristina Khan, Amir S. Alicea, Candido Kulkarni, Viraj Montefiori, David C. Venzon, David J. Patel, Vainav Felber, Barbara K. |
| Description | Author Affiliation: Rosati M ( Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.); |
| Abstract | Optimized plasmid DNAs encoding the majority of SIVmac239 proteins and delivered by electroporation (EP) elicited strong immune responses in rhesus macaques. Vaccination decreased viremia in both the acute and chronic phases of infection after challenge with pathogenic SIVmac251. Two groups of macaques were vaccinated with DNA plasmids producing different antigen forms, 'native' and 'modified,' inducing distinct immune responses. Both groups showed significantly lower viremia during the acute phase of infection, whereas the group immunized with the native antigens showed better protection during the chronic phase (1.7 log decrease in virus load, P = 0.009). Both groups developed strong cellular and humoral responses against the DNA vaccine antigens, which included Gag, Pol, Env, Nef, and Tat. Vaccination induced both central memory and effector memory T cells that were maintained at the day of challenge, suggesting the potential for rapid mobilization upon virus challenge. The group receiving the native antigens developed higher and more durable anti-Env antibodies, including neutralizing antibodies at the day of challenge. These results demonstrate that DNA vaccination in the absence of any heterologous boost can provide protection from high viremia comparable to any other vaccine modalities tested in this macaque model. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 37 |
| Volume Number | 106 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2009-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | SAIDS Vaccines Pharmacology Simian Acquired Immunodeficiency Syndrome Therapy Simian Immunodeficiency Virus Immunology Vaccines, DNA Viremia Prevention & Control Acute Disease Animals Antibodies, Viral Biosynthesis Antibody Specificity Antigens, Viral Genetics Chronic Disease Immunity, Cellular Immunization, Secondary Macaca Mulatta Administration & Dosage Pathogenicity Comparative Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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