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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Coleman, R. Edward Kelly, Susan J. Huffman, Kim M. Mcdaniel, Gary E. Hershfield, Michael S. Stabler, Thomas V. Denoble, Anna E. Kraus, Virginia B. |
| Description | Author Affiliation: Denoble AE ( Departments of Medicine and Radiology Duke University Medical Center, Durham, NC 27710, USA.); |
| Abstract | Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. When activated, the NLRP3 (also known as NALP3) inflammasome leads to the production of IL-18 and IL-1ß. In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1ß. Synovial fluid uric acid and IL-18 were strongly and positively associated with OA severity as measured by both radiograph and bone scintigraphy, and synovial fluid IL-1ß was associated with OA severity but only by radiograph. Furthermore, synovial fluid IL-18 was associated with a 3-y change in OA severity, on the basis of the radiograph. We conclude that synovial fluid uric acid is a marker of knee OA severity. The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1ß) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 5 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Knee Pathology Osteoarthritis Blood Uric Acid Carrier Proteins Genetics Cohort Studies Interleukin-1 Interleukin-18 Biosynthesis Immunology Risk Factors Severity Of Illness Index Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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