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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | White, Siobhan M. Basak, Chandramallika Erickson, Kirk I. Martin, Stephen A. Pence, Brandt D. Woods, Jeffrey A. Wojcicki, Thomas R. Vieira, Victoria J. Alves, Heloisa Kim, Jennifer S. Mailey, Emily Heo, Susie Szabo, Amanda Kramer, Arthur F. Mcauley, Edward Chaddock, Laura Voss, Michelle W. Prakash, Ruchika Shaurya |
| Description | Author Affiliation: Erickson KI ( Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.); |
| Abstract | The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. Hippocampal and medial temporal lobe volumes are larger in higher-fit adults, and physical activity training increases hippocampal perfusion, but the extent to which aerobic exercise training can modify hippocampal volume in late adulthood remains unknown. Here we show, in a randomized controlled trial with 120 older adults, that aerobic exercise training increases the size of the anterior hippocampus, leading to improvements in spatial memory. Exercise training increased hippocampal volume by 2%, effectively reversing age-related loss in volume by 1 to 2 y. We also demonstrate that increased hippocampal volume is associated with greater serum levels of BDNF, a mediator of neurogenesis in the dentate gyrus. Hippocampal volume declined in the control group, but higher preintervention fitness partially attenuated the decline, suggesting that fitness protects against volume loss. Caudate nucleus and thalamus volumes were unaffected by the intervention. These theoretically important findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved memory function. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Aging Physiology Hippocampus Anatomy & Histology Memory Space Perception Brain-Derived Neurotrophic Factor Blood Enzyme-Linked Immunosorbent Assay Magnetic Resonance Imaging Organ Size Randomized Controlled Trial Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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