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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Syková, Eva Pannasch, Ulrike Holcman, David Vargová, Lydia Reingruber, Jürgen Ezan, Pascal Giaume, Christian Rouach, Nathalie |
| Description | Author Affiliation: Pannasch U ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 7241/Institut National de la Santé et de la Recherche Médicale U1050, Collège de France, 75005 Paris, France.); |
| Abstract | Astrocytes dynamically interact with neurons to regulate synaptic transmission. Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic physiology is unknown. Here we show, by inactivating Cx30 and Cx43 genes, that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. This regulation limits neuronal excitability, release probability, and insertion of postsynaptic AMPA receptors, silencing synapses. By controlling synaptic strength, connexins play an important role in synaptic plasticity. Altogether, these results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Astrocytes Physiology Nerve Net Neuronal Plasticity Synaptic Transmission Animals Connexin 43 Connexins Gap Junctions Glutamic Acid Metabolism Hippocampus Mice Potassium Synapses Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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