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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Escrivà, Hector Somorjai, Ildikó M. L. Somorjai, Rajmund L. Garcia-fernàndez, Jordi |
| Spatial Coverage | France |
| Description | Author Affiliation: Somorjai IM ( Observatoire Océanologique de Banyuls-sur-Mer, Centre National de la Recherche Scientifique and Université Pierre et Marie Curie Paris VI, F-66650 Banyus-sur-Mer, France. somorjai@cantab.net); |
| Abstract | An important question in biology is why some animals are able to regenerate, whereas others are not. The basal chordate amphioxus is uniquely positioned to address the evolution of regeneration. We report here the high regeneration potential of the European amphioxus Branchiostoma lanceolatum. Adults regenerate both anterior and posterior structures, including neural tube, notochord, fin, and muscle. Development of a classifier based on tail regeneration profiles predicts the assignment of young and old adults to their own class with >94% accuracy. The process involves loss of differentiated characteristics, formation of an msx-expressing blastema, and neurogenesis. Moreover, regeneration is linked to the activation of satellite-like Pax3/7 progenitor cells, the extent of which declines with size and age. Our results provide a framework for understanding the evolution and diversity of regeneration mechanisms in vertebrates. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chordata, Nonvertebrate Physiology Regeneration Tail Animals DNA Primers Genetics In Situ Hybridization Larva Paired Box Transcription Factors Metabolism Stem Cells Time Factors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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