NDLI: Glut1-mediated glucose transport regulates HIV infection

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Glut1-mediated glucose transport regulates HIV infection

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Glut1-mediated glucose transport regulates HIV infection

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martinez, Marion Cosset, François-loic Loisel-meyer, Séverine Atkuri, Kondala R. Sitbon, Marc Battini, Jean-luc Swainson, Louise Herzenberg, Leonard A. Verhoeyen, Els Craveiro, Marco Mongellaz, Cédric Kinet, Sandrina Taylor, Naomi Costa, Caroline Herzenberg, Leonore A. Oburoglu, Leal
Description	Author Affiliation: Loisel-Meyer S ( Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5535, F-34293 Montpellier Cedex 5, France.);
Abstract	Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes, representing a large portion of the viral reservoir, are infected in vivo. Factors such as the homeostatic cytokine IL-7 have been shown to render quiescent T cells permissive to HIV-1 infection, presumably by transiently stimulating their entry into the cell cycle. However, we show here that at physiological oxygen $(O_{2})$ levels (2–5% $O_{2}$ tension in lymphoid organs), IL-7 stimulation generates an environment permissive to HIV-1 infection, despite a significantly attenuated level of cell cycle entry. We identify the IL-7–induced increase in Glut1 expression, resulting in augmented glucose uptake, as a key factor in rendering these T lymphocytes susceptible to HIV-1 infection. HIV-1 infection of human T cells is abrogated either by impairment of Glut1 signal transduction or by siRNA-mediated Glut1 down-regulation. Consistent with this, we show that the susceptibility of human thymocyte subsets to HIV-1 infection correlates with Glut1 expression; single-round infection is markedly higher in the Glut1-expressing double-positive thymocyte population than in any of the Glut1-negative subsets. Thus, our studies reveal the Glut1-mediated metabolic pathway as a critical regulator of HIV-1 infection in human CD4 T cells and thymocytes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glucose Transporter Type 1 Metabolism Glucose HIV Infections Physiopathology Biological Transport CD4-Positive T-Lymphocytes Signal Transduction Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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